Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses

PD-1 expression marks activated T cells susceptible to PD-1–mediated inhibition but not whether a PD-1–mediated signal is being delivered. Molecular predictors of response to PD-1 immune checkpoint blockade (ICB) are needed. We describe a monoclonal antibody (mAb) that detects PD-1 signaling through...

Descripción completa

Detalles Bibliográficos
Autores principales: Bu, Xia, Juneja, Vikram R., Reynolds, Carol G., Mahoney, Kathleen M., Bu, Melissa T., McGuire, Kathleen A., Maleri, Seth, Hua, Ping, Zhu, Baogong, Klein, Sarah R., Greenfield, Edward A., Armand, Philippe, Ritz, Jerome, Sharpe, Arlene H., Freeman, Gordon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642283/
https://www.ncbi.nlm.nih.gov/pubmed/34635486
http://dx.doi.org/10.1158/2326-6066.CIR-21-0493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642283/
https://www.ncbi.nlm.nih.gov/pubmed/34635486
http://dx.doi.org/10.1158/2326-6066.CIR-21-0493

Ejemplares similares