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Discovery of a potent FKBP38 agonist that ameliorates HFD-induced hyperlipidemia via mTOR/P70S6K/SREBPs pathway

The mammalian target of rapamycin (mTOR)-sterol regulatory element-binding proteins (SREBPs) signaling promotes lipogenesis. However, mTOR inhibitors also displayed a significant side effect of hyperlipidemia. Thus, it is essential to develop mTOR-specific inhibitors to inhibit lipogenesis. Here, we...

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Detalles Bibliográficos
Autores principales:	Xiao, Ping-Ting, Xie, Zhi-Shen, Kuang, Yu-Jia, Liu, Shi-Yu, Zeng, Chun, Li, Ping, Liu, E-Hu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642436/ https://www.ncbi.nlm.nih.gov/pubmed/34900535 http://dx.doi.org/10.1016/j.apsb.2021.03.031

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