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Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy
The field of two-dimensional (2D) nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines of material science, nano-chemistry, in particular nano-biological interactions, immunology, and medicinal chemistry. Most importantly, the “biological identity” of nanomaterials...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642437/ https://www.ncbi.nlm.nih.gov/pubmed/34900529 http://dx.doi.org/10.1016/j.apsb.2021.05.004 |
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author | Tang, Zhongmin Xiao, Yufen Kong, Na Liu, Chuang Chen, Wei Huang, Xiangang Xu, Daiyun Ouyang, Jiang Feng, Chan Wang, Cong Wang, Junqing Zhang, Han Tao, Wei |
author_facet | Tang, Zhongmin Xiao, Yufen Kong, Na Liu, Chuang Chen, Wei Huang, Xiangang Xu, Daiyun Ouyang, Jiang Feng, Chan Wang, Cong Wang, Junqing Zhang, Han Tao, Wei |
author_sort | Tang, Zhongmin |
collection | PubMed |
description | The field of two-dimensional (2D) nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines of material science, nano-chemistry, in particular nano-biological interactions, immunology, and medicinal chemistry. Most importantly, the “biological identity” of nanomaterials governed by bio-molecular corona in terms of bimolecular types, relative abundance, and conformation at the nanomaterial surface is now believed to influence blood circulation time, bio-distribution, immune response, cellular uptake, and intracellular trafficking. A better understanding of nano-bio interactions can improve utilization of 2D nano-architectures for cancer immunotherapy and immunotheranostics, allowing them to be adapted or modified to treat other immune dysregulation syndromes including autoimmune diseases or inflammation, infection, tissue regeneration, and transplantation. The manuscript reviews the biological interactions and immunotherapeutic applications of 2D nanomaterials, including understanding their interactions with biological molecules of the immune system, summarizes and prospects the applications of 2D nanomaterials in cancer immunotherapy. |
format | Online Article Text |
id | pubmed-8642437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-86424372021-12-09 Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy Tang, Zhongmin Xiao, Yufen Kong, Na Liu, Chuang Chen, Wei Huang, Xiangang Xu, Daiyun Ouyang, Jiang Feng, Chan Wang, Cong Wang, Junqing Zhang, Han Tao, Wei Acta Pharm Sin B Review The field of two-dimensional (2D) nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines of material science, nano-chemistry, in particular nano-biological interactions, immunology, and medicinal chemistry. Most importantly, the “biological identity” of nanomaterials governed by bio-molecular corona in terms of bimolecular types, relative abundance, and conformation at the nanomaterial surface is now believed to influence blood circulation time, bio-distribution, immune response, cellular uptake, and intracellular trafficking. A better understanding of nano-bio interactions can improve utilization of 2D nano-architectures for cancer immunotherapy and immunotheranostics, allowing them to be adapted or modified to treat other immune dysregulation syndromes including autoimmune diseases or inflammation, infection, tissue regeneration, and transplantation. The manuscript reviews the biological interactions and immunotherapeutic applications of 2D nanomaterials, including understanding their interactions with biological molecules of the immune system, summarizes and prospects the applications of 2D nanomaterials in cancer immunotherapy. Elsevier 2021-11 2021-05-16 /pmc/articles/PMC8642437/ /pubmed/34900529 http://dx.doi.org/10.1016/j.apsb.2021.05.004 Text en © 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Tang, Zhongmin Xiao, Yufen Kong, Na Liu, Chuang Chen, Wei Huang, Xiangang Xu, Daiyun Ouyang, Jiang Feng, Chan Wang, Cong Wang, Junqing Zhang, Han Tao, Wei Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy |
title | Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy |
title_full | Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy |
title_fullStr | Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy |
title_full_unstemmed | Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy |
title_short | Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy |
title_sort | nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642437/ https://www.ncbi.nlm.nih.gov/pubmed/34900529 http://dx.doi.org/10.1016/j.apsb.2021.05.004 |
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