Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS gain-of-function mutations are one of the leading causes in human oncogenesis, accounting for ∼19% of the global cancer burden. As a well-recognized target...

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Detalles Bibliográficos
Autores principales: Qiu, Yuran, Wang, Yuanhao, Chai, Zongtao, Ni, Duan, Li, Xinyi, Pu, Jun, Chen, Jie, Zhang, Jian, Lu, Shaoyong, Lv, Chuan, Ji, Mingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642438/
https://www.ncbi.nlm.nih.gov/pubmed/34900528
http://dx.doi.org/10.1016/j.apsb.2021.02.014

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