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Gains from no real PAINS: Where ‘Fair Trial Strategy’ stands in the development of multi-target ligands
Compounds that selectively modulate multiple targets can provide clinical benefits and are an alternative to traditional highly selective agents for unique targets. High-throughput screening (HTS) for multitarget-directed ligands (MTDLs) using approved drugs, and fragment-based drug design has becom...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642439/ https://www.ncbi.nlm.nih.gov/pubmed/34900527 http://dx.doi.org/10.1016/j.apsb.2021.02.023 |