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Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment

The goal of the present work was to examine clinical risk factors for mortality in 1375 COVID + patients admitted to a hospital in Suffolk County, NY. Data were collated by the hospital epidemiological service for patients admitted from 3/7/2020 to 9/1/2020. Time until final discharge or death was t...

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Autores principales: Clouston, Sean A. P., Luft, Benjamin J., Sun, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642440/
https://www.ncbi.nlm.nih.gov/pubmed/34862487
http://dx.doi.org/10.1038/s41598-021-02920-w
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author Clouston, Sean A. P.
Luft, Benjamin J.
Sun, Edward
author_facet Clouston, Sean A. P.
Luft, Benjamin J.
Sun, Edward
author_sort Clouston, Sean A. P.
collection PubMed
description The goal of the present work was to examine clinical risk factors for mortality in 1375 COVID + patients admitted to a hospital in Suffolk County, NY. Data were collated by the hospital epidemiological service for patients admitted from 3/7/2020 to 9/1/2020. Time until final discharge or death was the outcome. Cox proportional hazards models were used to estimate time until death among admitted patients. In total, all cases had resolved leading to 207 deaths. Length of stay was significantly longer in those who died as compared to those who did not (p = 0.007). Of patients who had been discharged, 54 were readmitted and nine subsequently died. Multivariable-adjusted Cox proportional hazards regression revealed that in addition to older age, male sex, and a history of chronic heart failure, chronic obstructive pulmonary disease, and diabetes, that a history of premorbid depression was a risk factors for COVID-19 mortality (aHR = 2.42 [1.38–4.23] P = 0.002), and that this association remained after adjusting for age and for neuropsychiatric conditions as well as medical comorbidities including cardiovascular disease and pulmonary conditions. Sex-stratified analyses revealed that associations between mortality and depression was strongest in males (aHR = 4.45 [2.04–9.72], P < 0.001), and that the association between heart failure and mortality was strongest in participants aged < 65 years old (aHR = 30.50 [9.17–101.48], P < 0.001). While an increasing number of studies have identified several comorbid medical conditions including chronic heart failure and age of patient as risk factors for mortality in COVID + patients, this study confirmed several prior reports and also noted that a history of depression is an independent risk factor for COVID-19 mortality.
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spelling pubmed-86424402021-12-06 Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment Clouston, Sean A. P. Luft, Benjamin J. Sun, Edward Sci Rep Article The goal of the present work was to examine clinical risk factors for mortality in 1375 COVID + patients admitted to a hospital in Suffolk County, NY. Data were collated by the hospital epidemiological service for patients admitted from 3/7/2020 to 9/1/2020. Time until final discharge or death was the outcome. Cox proportional hazards models were used to estimate time until death among admitted patients. In total, all cases had resolved leading to 207 deaths. Length of stay was significantly longer in those who died as compared to those who did not (p = 0.007). Of patients who had been discharged, 54 were readmitted and nine subsequently died. Multivariable-adjusted Cox proportional hazards regression revealed that in addition to older age, male sex, and a history of chronic heart failure, chronic obstructive pulmonary disease, and diabetes, that a history of premorbid depression was a risk factors for COVID-19 mortality (aHR = 2.42 [1.38–4.23] P = 0.002), and that this association remained after adjusting for age and for neuropsychiatric conditions as well as medical comorbidities including cardiovascular disease and pulmonary conditions. Sex-stratified analyses revealed that associations between mortality and depression was strongest in males (aHR = 4.45 [2.04–9.72], P < 0.001), and that the association between heart failure and mortality was strongest in participants aged < 65 years old (aHR = 30.50 [9.17–101.48], P < 0.001). While an increasing number of studies have identified several comorbid medical conditions including chronic heart failure and age of patient as risk factors for mortality in COVID + patients, this study confirmed several prior reports and also noted that a history of depression is an independent risk factor for COVID-19 mortality. Nature Publishing Group UK 2021-12-03 /pmc/articles/PMC8642440/ /pubmed/34862487 http://dx.doi.org/10.1038/s41598-021-02920-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Clouston, Sean A. P.
Luft, Benjamin J.
Sun, Edward
Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment
title Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment
title_full Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment
title_fullStr Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment
title_full_unstemmed Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment
title_short Clinical risk factors for mortality in an analysis of 1375 patients admitted for COVID treatment
title_sort clinical risk factors for mortality in an analysis of 1375 patients admitted for covid treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642440/
https://www.ncbi.nlm.nih.gov/pubmed/34862487
http://dx.doi.org/10.1038/s41598-021-02920-w
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