Cargando…

The deubiquitinase OTUB1 fosters papillary thyroid carcinoma growth through EYA1 stabilization

Deubiquitinating enzyme OTU domain‐containing ubiquitin aldehyde‐binding proteins 1 (OTUB1) has been shown to have an essential role in multiple carcinomas. However, the function of OTUB1 in papillary thyroid cancer (PTC) and the underlying mechanisms regulating PTC cells proliferation remain poorly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Peiyi, Chao, Qing, Mao, Jiuang, Liu, Yue, Fang, Jiayu, Xie, Jing, Zhen, Jing, Ding, Yongqi, Fu, Bidong, Ke, Yun, Huang, Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642681/ https://www.ncbi.nlm.nih.gov/pubmed/34773364 http://dx.doi.org/10.1111/jcmm.17020

Ejemplares similares

The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism
por: Ruiz-Serrano, Amalia, et al.
Publicado: (2022)

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
por: Scholz, Carsten C., et al.
Publicado: (2016)

The deubiquitinase Otub1 controls the activation of CD8 T cells and NK cells by regulating IL-15-mediated priming
por: Zhou, Xiaofei, et al.
Publicado: (2019)

The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma
por: Xie, Peiyi, et al.
Publicado: (2021)

The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13
por: Mulas, Floriana, et al.
Publicado: (2020)

ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1
por: Zhong, Xiaodan, et al.
Publicado: (2022)

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo
por: Wang, Peng, et al.
Publicado: (2017)

OTUB1 inhibits breast cancer by non‐canonically stabilizing CCN6
por: Zhao, Ying, et al.
Publicado: (2023)

Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria
por: Chen, Yingxiao, et al.
Publicado: (2016)

The mechanism of OTUB1 inhibition of ubiquitination
por: Wiener, Reuven, et al.
Publicado: (2012)

OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination
por: Wu, Qiong, et al.
Publicado: (2021)

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2
por: Zhu, Qiong, et al.
Publicado: (2023)

BOR-Syndrome-Associated Eya1 Mutations Lead to Enhanced Proteasomal Degradation of Eya1 Protein
por: Musharraf, Amna, et al.
Publicado: (2014)

Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield
por: Wang, Shuansuo, et al.
Publicado: (2017)

MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma
por: Fang, Jiayu, et al.
Publicado: (2022)

The role of Eya1 and Eya2 in the taste system of mice from embryonic stage to adulthood
por: Zhang, Ting, et al.
Publicado: (2023)

CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1
por: Li, Dongbao, et al.
Publicado: (2022)

Eya mater
Publicado: (1995)

Reducing expression of TaOTUB1s decreases tiller number in wheat
por: Jiang, Deng Ji, et al.
Publicado: (2021)

Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains
por: Lu, Lining, et al.
Publicado: (2022)

SET7 methylates the deubiquitinase OTUB1 at Lys (122) to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis
por: Deng, Hongyan, et al.
Publicado: (2023)

SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1
por: Kong, Deguang, et al.
Publicado: (2019)

The Deubiquitinase USP4 Stabilizes Twist1 Protein to Promote Lung Cancer Cell Stemness
por: Li, Fengtian, et al.
Publicado: (2020)

Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells
por: Chen, Shanwen, et al.
Publicado: (2021)

OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress
por: Zhang, Hui‐Hui, et al.
Publicado: (2021)

OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation
por: Koschel, Josephin, et al.
Publicado: (2021)

The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor
por: Bi, Hai-Lian, et al.
Publicado: (2020)

SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases
por: Xu, Baoyan, et al.
Publicado: (2021)

OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
por: Baietti, Maria Francesca, et al.
Publicado: (2016)

Correction: OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation
por: Koschel, Josephin, et al.
Publicado: (2021)

Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1
por: Zhang, Zhiwei, et al.
Publicado: (2021)

Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
por: Sun, Tong, et al.
Publicado: (2021)

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance
por: Karunarathna, U, et al.
Publicado: (2016)

OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination
por: Pasupala, Nagesh, et al.
Publicado: (2018)

E2 ubiquitin conjugating enzymes regulate the deubiquitinating activity of OTUB1
por: Wiener, Reuven, et al.
Publicado: (2013)

OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression
por: Lee, Bok-Soon, et al.
Publicado: (2021)

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
por: Zhang, Shengzhe, et al.
Publicado: (2018)

Otic Neurogenesis in Xenopus laevis: Proliferation, Differentiation, and the Role of Eya1
por: Almasoudi, Suad Hamdan, et al.
Publicado: (2021)

Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression
por: Liu, Tao, et al.
Publicado: (2023)

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo
por: Iglesias-Gato, Diego, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qdq8onufqgavppttcpdfod2upl