Cargando…

Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development

Cancer is a complex multifactorial process, unchecked and abrupt division, and cell growth—conventional chemotherapy, along with radiotherapy, is used to treat breast cancer. Due to reduce efficacy and less survival rate, there is a particular need for the discovery of new active anticancer agents....

Descripción completa

Detalles Bibliográficos
Autores principales: Chaudhry, Gul-e-Saba, Jan, Rehmat, Akim, Abdah, Zafar, Muhammad Naveed, Sung, Yeong Yik, Muhammad, Tengku Sifzizul Tengku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642807/
https://www.ncbi.nlm.nih.gov/pubmed/34888205
http://dx.doi.org/10.34172/apb.2021.068
_version_ 1784609747900563456
author Chaudhry, Gul-e-Saba
Jan, Rehmat
Akim, Abdah
Zafar, Muhammad Naveed
Sung, Yeong Yik
Muhammad, Tengku Sifzizul Tengku
author_facet Chaudhry, Gul-e-Saba
Jan, Rehmat
Akim, Abdah
Zafar, Muhammad Naveed
Sung, Yeong Yik
Muhammad, Tengku Sifzizul Tengku
author_sort Chaudhry, Gul-e-Saba
collection PubMed
description Cancer is a complex multifactorial process, unchecked and abrupt division, and cell growth—conventional chemotherapy, along with radiotherapy, is used to treat breast cancer. Due to reduce efficacy and less survival rate, there is a particular need for the discovery of new active anticancer agents. Natural resources such as terrestrial/marine plants or organisms are a promising source for the generation of new therapeutics with improving efficacy. The screening of natural plant extracts and fractions, isolations of phytochemicals, and mechanistic study of those potential compounds play a remarkable role in the development of new therapeutic drugs with increased efficacy. Cancer is a multistage disease with complex signaling cascades. The initial study of screening whole extracts or fractions and later the isolation of secondary compounds and their mechanism of action study gives a clue of potential therapeutic agents for future drug development. The phytochemicals present in extracts/fractions produce remarkable effects due to synergistically targeting multiple signals. In this review, the molecular targets of extracts/ fractions and isolated compounds highlighted. The therapeutic agent's mechanistic targets in drug development focused involves; i) Induction of Apoptosis, ii) modulating cell cycle arrest, iii) Inhibition or suppression of invasion and metastasis and iv) various other pro-survival signaling pathways. The phytochemicals and their modified analogs identified as future potential candidates for anticancer chemotherapy.
format Online
Article
Text
id pubmed-8642807
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Tabriz University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-86428072021-12-08 Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development Chaudhry, Gul-e-Saba Jan, Rehmat Akim, Abdah Zafar, Muhammad Naveed Sung, Yeong Yik Muhammad, Tengku Sifzizul Tengku Adv Pharm Bull Review Article Cancer is a complex multifactorial process, unchecked and abrupt division, and cell growth—conventional chemotherapy, along with radiotherapy, is used to treat breast cancer. Due to reduce efficacy and less survival rate, there is a particular need for the discovery of new active anticancer agents. Natural resources such as terrestrial/marine plants or organisms are a promising source for the generation of new therapeutics with improving efficacy. The screening of natural plant extracts and fractions, isolations of phytochemicals, and mechanistic study of those potential compounds play a remarkable role in the development of new therapeutic drugs with increased efficacy. Cancer is a multistage disease with complex signaling cascades. The initial study of screening whole extracts or fractions and later the isolation of secondary compounds and their mechanism of action study gives a clue of potential therapeutic agents for future drug development. The phytochemicals present in extracts/fractions produce remarkable effects due to synergistically targeting multiple signals. In this review, the molecular targets of extracts/ fractions and isolated compounds highlighted. The therapeutic agent's mechanistic targets in drug development focused involves; i) Induction of Apoptosis, ii) modulating cell cycle arrest, iii) Inhibition or suppression of invasion and metastasis and iv) various other pro-survival signaling pathways. The phytochemicals and their modified analogs identified as future potential candidates for anticancer chemotherapy. Tabriz University of Medical Sciences 2021-09 2020-10-14 /pmc/articles/PMC8642807/ /pubmed/34888205 http://dx.doi.org/10.34172/apb.2021.068 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
spellingShingle Review Article
Chaudhry, Gul-e-Saba
Jan, Rehmat
Akim, Abdah
Zafar, Muhammad Naveed
Sung, Yeong Yik
Muhammad, Tengku Sifzizul Tengku
Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development
title Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development
title_full Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development
title_fullStr Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development
title_full_unstemmed Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development
title_short Breast Cancer: A Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development
title_sort breast cancer: a global concern, diagnostic and therapeutic perspectives, mechanistic targets in drug development
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642807/
https://www.ncbi.nlm.nih.gov/pubmed/34888205
http://dx.doi.org/10.34172/apb.2021.068
work_keys_str_mv AT chaudhrygulesaba breastcanceraglobalconcerndiagnosticandtherapeuticperspectivesmechanistictargetsindrugdevelopment
AT janrehmat breastcanceraglobalconcerndiagnosticandtherapeuticperspectivesmechanistictargetsindrugdevelopment
AT akimabdah breastcanceraglobalconcerndiagnosticandtherapeuticperspectivesmechanistictargetsindrugdevelopment
AT zafarmuhammadnaveed breastcanceraglobalconcerndiagnosticandtherapeuticperspectivesmechanistictargetsindrugdevelopment
AT sungyeongyik breastcanceraglobalconcerndiagnosticandtherapeuticperspectivesmechanistictargetsindrugdevelopment
AT muhammadtengkusifzizultengku breastcanceraglobalconcerndiagnosticandtherapeuticperspectivesmechanistictargetsindrugdevelopment