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IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors

BACKGROUND: Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is regulated in metastatic microenvironment caused by colorectal cancer is still un...

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Detalles Bibliográficos
Autores principales:	Jin, Qian, Yang, He, Jing, Zhao, Hong-hua, Wu, Ben-jing, Song, Li-ting, Wang, Li-juan, Ye, Wei, Xu, Xia, Kang, Juan, Wu, Wei, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642926/ https://www.ncbi.nlm.nih.gov/pubmed/34863091 http://dx.doi.org/10.1186/s10020-021-00411-2

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