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An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis

BACKGROUND: Adrenal tuberculosis is difficult to diagnose due to non-specific symptom. Unexpected death due to adrenal insufficiency after trauma surgery is rare. CASE PRESENTATION: A 45-year-old man, who was admitted to hospital because of trauma to the right hand, died unexpectedly on the 13th day...

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Autores principales: Zhao, Nan, Gao, Yutong, Ni, Chunsheng, Zhang, Danfang, Zhao, Xiulan, Li, Yanlei, Sun, Baocun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642993/
https://www.ncbi.nlm.nih.gov/pubmed/34863306
http://dx.doi.org/10.1186/s40001-021-00611-w
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author Zhao, Nan
Gao, Yutong
Ni, Chunsheng
Zhang, Danfang
Zhao, Xiulan
Li, Yanlei
Sun, Baocun
author_facet Zhao, Nan
Gao, Yutong
Ni, Chunsheng
Zhang, Danfang
Zhao, Xiulan
Li, Yanlei
Sun, Baocun
author_sort Zhao, Nan
collection PubMed
description BACKGROUND: Adrenal tuberculosis is difficult to diagnose due to non-specific symptom. Unexpected death due to adrenal insufficiency after trauma surgery is rare. CASE PRESENTATION: A 45-year-old man, who was admitted to hospital because of trauma to the right hand, died unexpectedly on the 13th day after replantation of amputated fingers. He was diagnosed with brain edema and diluted hyponatremia. Autopsy and histopathologic examination revealed severe brain edema combined with cerebellar tonsillar hernia, extensive destruction of adrenal gland caused by bilateral adrenal tuberculosis and right lung invasive pulmonary tuberculosis. CONCLUSIONS: Trauma and pulmonary tuberculosis complicated with adrenal tuberculosis induced the adrenal crisis, which eventually lead to severe cerebral edema and hernia, and finally death from respiratory and circulatory failure. This autopsy and histopathologic examination suggested a possible pathophysiologic mechanism of sudden death due to diluted hyponatremia after trauma surgery.
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spelling pubmed-86429932021-12-06 An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis Zhao, Nan Gao, Yutong Ni, Chunsheng Zhang, Danfang Zhao, Xiulan Li, Yanlei Sun, Baocun Eur J Med Res Case Report BACKGROUND: Adrenal tuberculosis is difficult to diagnose due to non-specific symptom. Unexpected death due to adrenal insufficiency after trauma surgery is rare. CASE PRESENTATION: A 45-year-old man, who was admitted to hospital because of trauma to the right hand, died unexpectedly on the 13th day after replantation of amputated fingers. He was diagnosed with brain edema and diluted hyponatremia. Autopsy and histopathologic examination revealed severe brain edema combined with cerebellar tonsillar hernia, extensive destruction of adrenal gland caused by bilateral adrenal tuberculosis and right lung invasive pulmonary tuberculosis. CONCLUSIONS: Trauma and pulmonary tuberculosis complicated with adrenal tuberculosis induced the adrenal crisis, which eventually lead to severe cerebral edema and hernia, and finally death from respiratory and circulatory failure. This autopsy and histopathologic examination suggested a possible pathophysiologic mechanism of sudden death due to diluted hyponatremia after trauma surgery. BioMed Central 2021-12-04 /pmc/articles/PMC8642993/ /pubmed/34863306 http://dx.doi.org/10.1186/s40001-021-00611-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Zhao, Nan
Gao, Yutong
Ni, Chunsheng
Zhang, Danfang
Zhao, Xiulan
Li, Yanlei
Sun, Baocun
An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_full An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_fullStr An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_full_unstemmed An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_short An autopsy case of unexpected death due to Addison’s disease caused by adrenal tuberculosis
title_sort autopsy case of unexpected death due to addison’s disease caused by adrenal tuberculosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642993/
https://www.ncbi.nlm.nih.gov/pubmed/34863306
http://dx.doi.org/10.1186/s40001-021-00611-w
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