Cargando…
Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity
The mouse model of oxygen induced retinopathy is suitable for the study of various retinal neovascularization diseases, including retinopathy of prematurity. The maternally expressed gene 3 (MEG3) has been demonstrated to have an inhibitory effect on diabetic retinopathy. In this study, we investiga...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643049/ https://www.ncbi.nlm.nih.gov/pubmed/34782583 http://dx.doi.org/10.4103/1673-5374.327358 |
_version_ | 1784609801392619520 |
---|---|
author | Di, Yu Wang, Yue Wang, Yue-Xia Wang, Xue Ma, Yuan Nie, Qing-Zhu |
author_facet | Di, Yu Wang, Yue Wang, Yue-Xia Wang, Xue Ma, Yuan Nie, Qing-Zhu |
author_sort | Di, Yu |
collection | PubMed |
description | The mouse model of oxygen induced retinopathy is suitable for the study of various retinal neovascularization diseases, including retinopathy of prematurity. The maternally expressed gene 3 (MEG3) has been demonstrated to have an inhibitory effect on diabetic retinopathy. In this study, we investigated the role of MEG3 overexpression in oxygen-induced retinopathy in mice. The results showed that MEG3 overexpression effectively inhibited the production of retinal neovascularization in oxygen-induced retinopathy mice. It acts by down-regulating the expression of phosphoinositide 3-kinase, serine/threonine kinase, and vascular endothelial growth factor and pro-inflammatory factors. MEG3 overexpression lentivirus has a future as a new method for the clinical treatment of retinopathy of prematurity. The animal experiments were approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University, China (approval No. 2016PS074K) on February 25, 2016. |
format | Online Article Text |
id | pubmed-8643049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-86430492021-12-14 Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity Di, Yu Wang, Yue Wang, Yue-Xia Wang, Xue Ma, Yuan Nie, Qing-Zhu Neural Regen Res Research Article The mouse model of oxygen induced retinopathy is suitable for the study of various retinal neovascularization diseases, including retinopathy of prematurity. The maternally expressed gene 3 (MEG3) has been demonstrated to have an inhibitory effect on diabetic retinopathy. In this study, we investigated the role of MEG3 overexpression in oxygen-induced retinopathy in mice. The results showed that MEG3 overexpression effectively inhibited the production of retinal neovascularization in oxygen-induced retinopathy mice. It acts by down-regulating the expression of phosphoinositide 3-kinase, serine/threonine kinase, and vascular endothelial growth factor and pro-inflammatory factors. MEG3 overexpression lentivirus has a future as a new method for the clinical treatment of retinopathy of prematurity. The animal experiments were approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University, China (approval No. 2016PS074K) on February 25, 2016. Wolters Kluwer - Medknow 2021-11-12 /pmc/articles/PMC8643049/ /pubmed/34782583 http://dx.doi.org/10.4103/1673-5374.327358 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Di, Yu Wang, Yue Wang, Yue-Xia Wang, Xue Ma, Yuan Nie, Qing-Zhu Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity |
title | Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity |
title_full | Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity |
title_fullStr | Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity |
title_full_unstemmed | Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity |
title_short | Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity |
title_sort | maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643049/ https://www.ncbi.nlm.nih.gov/pubmed/34782583 http://dx.doi.org/10.4103/1673-5374.327358 |
work_keys_str_mv | AT diyu maternallyexpressedgene3regulatesretinalneovascularizationinretinopathyofprematurity AT wangyue maternallyexpressedgene3regulatesretinalneovascularizationinretinopathyofprematurity AT wangyuexia maternallyexpressedgene3regulatesretinalneovascularizationinretinopathyofprematurity AT wangxue maternallyexpressedgene3regulatesretinalneovascularizationinretinopathyofprematurity AT mayuan maternallyexpressedgene3regulatesretinalneovascularizationinretinopathyofprematurity AT nieqingzhu maternallyexpressedgene3regulatesretinalneovascularizationinretinopathyofprematurity |