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Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada

BACKGROUND: Inflammatory bowel disease (IBD) is now a global disease with incidence increasing throughout Asia. AIM: To determine the incidence of IBD among South Asians and Chinese people residing in Ontario, Canada’s most populous province. METHODS: All incident cases of IBD in children (1994–2015...

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Autores principales: Dhaliwal, Jasbir, Tuna, Meltem, Shah, Baiju R, Murthy, Sanjay, Herrett, Emily, Griffiths, Anne M, Benchimol, Eric I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643128/
https://www.ncbi.nlm.nih.gov/pubmed/34876857
http://dx.doi.org/10.2147/CLEP.S336517
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author Dhaliwal, Jasbir
Tuna, Meltem
Shah, Baiju R
Murthy, Sanjay
Herrett, Emily
Griffiths, Anne M
Benchimol, Eric I
author_facet Dhaliwal, Jasbir
Tuna, Meltem
Shah, Baiju R
Murthy, Sanjay
Herrett, Emily
Griffiths, Anne M
Benchimol, Eric I
author_sort Dhaliwal, Jasbir
collection PubMed
description BACKGROUND: Inflammatory bowel disease (IBD) is now a global disease with incidence increasing throughout Asia. AIM: To determine the incidence of IBD among South Asians and Chinese people residing in Ontario, Canada’s most populous province. METHODS: All incident cases of IBD in children (1994–2015) and adults (1999–2015) were identified from population-based health administrative data. We classified South Asian and Chinese ethnicity using immigration records and surnames. We determined standardized incidence of IBD and adjusted incidence rate ratio (aIRR) in South Asians and Chinese compared to the general population. RESULTS: Among 16,230,638 people living in Ontario, standardized incidence of IBD per 100,000 person-years was 24.7 (95% CI 24.4–25.0), compared with 14.6 (95% CI 13.7–15.5) in 982,472 South Asians and with 5.4 (95% CI 4.8–5.9) in 764,397 Chinese. The risk of IBD in South Asians was comparable to the general population after adjusting for immigrant status and confounders (aIRR 1.03, 95% CI 0.96–1.10). South Asians had a lower risk of Crohn’s disease (CD) (aIRR 0.66, 95% CI 0.60–0.77), but a higher risk of ulcerative colitis (UC) (aIRR 1.47, 95% CI 1.34–1.61). Chinese people had much lower rates of IBD (aIRR 0.24, 95% CI 0.20–0.28), CD (aIRR 0.21, 95% CI 0.17–0.26), and UC (aIRR 0.28, 95% CI 0.23–0.25). CONCLUSION: Canadians of South Asian ethnicity had a similarly high risk of developing IBD compared to other Canadians, and a higher risk of developing UC, a finding distinct from the Chinese population. Our findings indicate the importance of genetic and environmental risk factors in people of Asian origin who live in the Western world.
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spelling pubmed-86431282021-12-06 Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada Dhaliwal, Jasbir Tuna, Meltem Shah, Baiju R Murthy, Sanjay Herrett, Emily Griffiths, Anne M Benchimol, Eric I Clin Epidemiol Original Research BACKGROUND: Inflammatory bowel disease (IBD) is now a global disease with incidence increasing throughout Asia. AIM: To determine the incidence of IBD among South Asians and Chinese people residing in Ontario, Canada’s most populous province. METHODS: All incident cases of IBD in children (1994–2015) and adults (1999–2015) were identified from population-based health administrative data. We classified South Asian and Chinese ethnicity using immigration records and surnames. We determined standardized incidence of IBD and adjusted incidence rate ratio (aIRR) in South Asians and Chinese compared to the general population. RESULTS: Among 16,230,638 people living in Ontario, standardized incidence of IBD per 100,000 person-years was 24.7 (95% CI 24.4–25.0), compared with 14.6 (95% CI 13.7–15.5) in 982,472 South Asians and with 5.4 (95% CI 4.8–5.9) in 764,397 Chinese. The risk of IBD in South Asians was comparable to the general population after adjusting for immigrant status and confounders (aIRR 1.03, 95% CI 0.96–1.10). South Asians had a lower risk of Crohn’s disease (CD) (aIRR 0.66, 95% CI 0.60–0.77), but a higher risk of ulcerative colitis (UC) (aIRR 1.47, 95% CI 1.34–1.61). Chinese people had much lower rates of IBD (aIRR 0.24, 95% CI 0.20–0.28), CD (aIRR 0.21, 95% CI 0.17–0.26), and UC (aIRR 0.28, 95% CI 0.23–0.25). CONCLUSION: Canadians of South Asian ethnicity had a similarly high risk of developing IBD compared to other Canadians, and a higher risk of developing UC, a finding distinct from the Chinese population. Our findings indicate the importance of genetic and environmental risk factors in people of Asian origin who live in the Western world. Dove 2021-11-30 /pmc/articles/PMC8643128/ /pubmed/34876857 http://dx.doi.org/10.2147/CLEP.S336517 Text en © 2021 Dhaliwal et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Dhaliwal, Jasbir
Tuna, Meltem
Shah, Baiju R
Murthy, Sanjay
Herrett, Emily
Griffiths, Anne M
Benchimol, Eric I
Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada
title Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada
title_full Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada
title_fullStr Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada
title_full_unstemmed Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada
title_short Incidence of Inflammatory Bowel Disease in South Asian and Chinese People: A Population-Based Cohort Study from Ontario, Canada
title_sort incidence of inflammatory bowel disease in south asian and chinese people: a population-based cohort study from ontario, canada
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643128/
https://www.ncbi.nlm.nih.gov/pubmed/34876857
http://dx.doi.org/10.2147/CLEP.S336517
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