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Analysis of Serum Metabolomics in Obese Mice Induced by High-Fat Diet
BACKGROUND: Obesity is a public health problem all over the world, and dietary habits are considered one of the important reasons. METHODS: In this study, serum metabolites of mice fed a normal or high-fat diet (HFD) were analyzed using UPLC-QTOF-MS. RESULTS: A significant increase in body weight wa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643162/ https://www.ncbi.nlm.nih.gov/pubmed/34876827 http://dx.doi.org/10.2147/DMSO.S337979 |
Sumario: | BACKGROUND: Obesity is a public health problem all over the world, and dietary habits are considered one of the important reasons. METHODS: In this study, serum metabolites of mice fed a normal or high-fat diet (HFD) were analyzed using UPLC-QTOF-MS. RESULTS: A significant increase in body weight was noted in HFD mice. The HFD and control groups were significantly different from each other on OPLS-DA scores. The major metabolites contributing to obesity were lipid metabolites (phosphatidylcholines, phosphatidylethanolamine, and lysophosphatidylcholines). In addition, this study revealed that glycerophospholipid metabolism, α-linolenic acid metabolism, and linoleic acid metabolism were related to obesity and obesity-associated diseases. CONCLUSION: These results can be used to better understand obesity and assess its risk, which will provide new ideas for treatment. |
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