Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation

MYC upregulation is associated with multidrug refractory disease in patients with multiple myeloma (MM). We, isolated patient-derived MM cells with high MYC expression and discovered that NCOR2 was down-regulated in these cells. NCOR2 is a transcriptional coregulatory protein and its role in MM rema...

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Detalles Bibliográficos
Autores principales: Mori, Tomoaki, Verma, Rakesh, Nakamoto-Matsubara, Rie, Siu, Ka Tat, Panaroni, Cristina, Fulzele, Keertik S., Mukaihara, Kenta, Onyewadume, Chukwuamaka, Maebius, Allison, Kato, Hiroki, Wong, Lai Ping, Sadreyev, Ruslan I., Scadden, David T., Raje, Noopur S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643354/
https://www.ncbi.nlm.nih.gov/pubmed/34864816
http://dx.doi.org/10.1038/s41408-021-00589-y

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