Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model

BACKGROUND: Medulloblastomas with chromothripsis developing in children with Li-Fraumeni Syndrome (germline TP53 mutations) are highly aggressive brain tumors with dismal prognosis. Conventional photon radiotherapy and DNA-damaging chemotherapy are not successful for these patients and raise the ris...

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Detalles Bibliográficos
Autores principales: Simovic, Milena, Bolkestein, Michiel, Moustafa, Mahmoud, Wong, John K L, Körber, Verena, Benedetto, Sarah, Khalid, Umar, Schreiber, Hannah Sophia, Jugold, Manfred, Korshunov, Andrey, Hübschmann, Daniel, Mack, Norman, Brons, Stephan, Wei, Pei-Chi, Breckwoldt, Michael O, Heiland, Sabine, Bendszus, Martin, Debus, Jürgen, Höfer, Thomas, Zapatka, Marc, Kool, Marcel, Pfister, Stefan M, Abdollahi, Amir, Ernst, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643436/
https://www.ncbi.nlm.nih.gov/pubmed/34049392
http://dx.doi.org/10.1093/neuonc/noab127

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