WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

Many hereditary cancer syndromes are associated with an increased risk of small and large intestinal adenocarcinomas. However, conditions bearing a high risk to both adenocarcinomas and neuroendocrine tumors are yet to be described. We studied a family with 16 individuals in four generations affecte...

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Autores principales: Aavikko, Mervi, Kaasinen, Eevi, Andersson, Noora, Pentinmikko, Nalle, Sulo, Päivi, Donner, Iikki, Pihlajamaa, Päivi, Kuosmanen, Anna, Bramante, Simona, Katainen, Riku, Sipilä, Lauri J, Martin, Samantha, Arola, Johanna, Carpén, Olli, Heiskanen, Ilkka, Mecklin, Jukka-Pekka, Taipale, Jussi, Ristimäki, Ari, Lehti, Kaisa, Gucciardo, Erika, Katajisto, Pekka, Schalin-Jäntti, Camilla, Vahteristo, Pia, Aaltonen, Lauri A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643507/
https://www.ncbi.nlm.nih.gov/pubmed/34274970
http://dx.doi.org/10.1093/hmg/ddab206

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