Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis

BACKGROUND: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto’s thyroiditis (HT) and healthy controls (HC). METHODS: The relative mtDNAcn and oxidative DNA damage in this case-control study were mea...

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Autores principales: Esfahanian, Fatemeh, Hazaveh, Mojgan Mirabdolhagh, Garehbagh, Laya Hooshmand, Falahati, Kowsar, Ataei, Mitra, Sanati, Mohammad Hossein, Jadali, Zohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643530/
https://www.ncbi.nlm.nih.gov/pubmed/34917541
http://dx.doi.org/10.18502/ijph.v50i8.6817
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author Esfahanian, Fatemeh
Hazaveh, Mojgan Mirabdolhagh
Garehbagh, Laya Hooshmand
Falahati, Kowsar
Ataei, Mitra
Sanati, Mohammad Hossein
Jadali, Zohreh
author_facet Esfahanian, Fatemeh
Hazaveh, Mojgan Mirabdolhagh
Garehbagh, Laya Hooshmand
Falahati, Kowsar
Ataei, Mitra
Sanati, Mohammad Hossein
Jadali, Zohreh
author_sort Esfahanian, Fatemeh
collection PubMed
description BACKGROUND: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto’s thyroiditis (HT) and healthy controls (HC). METHODS: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. RESULTS: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. CONCLUSION: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.
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spelling pubmed-86435302021-12-15 Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis Esfahanian, Fatemeh Hazaveh, Mojgan Mirabdolhagh Garehbagh, Laya Hooshmand Falahati, Kowsar Ataei, Mitra Sanati, Mohammad Hossein Jadali, Zohreh Iran J Public Health Original Article BACKGROUND: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto’s thyroiditis (HT) and healthy controls (HC). METHODS: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. RESULTS: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. CONCLUSION: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT. Tehran University of Medical Sciences 2021-08 /pmc/articles/PMC8643530/ /pubmed/34917541 http://dx.doi.org/10.18502/ijph.v50i8.6817 Text en Copyright © 2021 Esfahanian et al. Published by Tehran University of Medical Sciences https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Esfahanian, Fatemeh
Hazaveh, Mojgan Mirabdolhagh
Garehbagh, Laya Hooshmand
Falahati, Kowsar
Ataei, Mitra
Sanati, Mohammad Hossein
Jadali, Zohreh
Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
title Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
title_full Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
title_fullStr Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
title_full_unstemmed Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
title_short Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto’s Thyroiditis
title_sort increased mitochondrial dna copy number and oxidative damage in patients with hashimoto’s thyroiditis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643530/
https://www.ncbi.nlm.nih.gov/pubmed/34917541
http://dx.doi.org/10.18502/ijph.v50i8.6817
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