Cargando…

Enzymatic deamination of the epigenetic nucleoside N(6)-methyladenosine regulates gene expression

N(6)-methyladenosine (m(6)A) modification is the most extensively studied epigenetic modification due to its crucial role in regulating an array of biological processes. Herein, Bsu06560, formerly annotated as an adenine deaminase derived from Bacillus subtilis 168, was recognized as the first enzym...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Zhuoran, Wang, Chao, Wu, Zixin, Chen, Kun, Yang, Wei, Deng, Hexiang, Song, Heng, Zhou, Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643624/ https://www.ncbi.nlm.nih.gov/pubmed/34850126 http://dx.doi.org/10.1093/nar/gkab1124

Ejemplares similares

Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera
por: Ji, Debin, et al.
Publicado: (2017)

Towards a comprehensive understanding of RNA deamination: synthesis and properties of xanthosine-modified RNA
por: Mair, Stefan, et al.
Publicado: (2022)

Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics
por: Wei, Yue, et al.
Publicado: (2021)

N (4)-acyl-2′-deoxycytidine-5′-triphosphates for the enzymatic synthesis of modified DNA
por: Jakubovska, Jevgenija, et al.
Publicado: (2018)

Nucleoside analogs to manage sequence divergence in nucleic acid amplification and SNP detection
por: Yang, Zunyi, et al.
Publicado: (2018)

Zebrafish AID is capable of deaminating methylated deoxycytidines
por: Abdouni, Hala, et al.
Publicado: (2013)

A strongly pairing fifth base: oligonucleotides with a C-nucleoside replacing thymidine
por: Walter, Tanja J, et al.
Publicado: (2018)

Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface
por: Okamura, Hidenori, et al.
Publicado: (2022)

Defining the functional footprint for recognition and repair of deaminated DNA
por: Baldwin, Michael R., et al.
Publicado: (2012)

Reversible manipulation of the G-quadruplex structures and enzymatic reactions through supramolecular host–guest interactions
por: Tian, Tian, et al.
Publicado: (2017)

Probing G-quadruplex topologies and recognition concurrently in real time and 3D using a dual-app nucleoside probe
por: Nuthanakanti, Ashok, et al.
Publicado: (2019)

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative
por: Scuotto, Maria, et al.
Publicado: (2015)

Stabilization and structural changes of 2D DNA origami by enzymatic ligation
por: Rajendran, Arivazhagan, et al.
Publicado: (2021)

One-step enzymatic modification of RNA 3′ termini using polymerase θ
por: Thomas, Crystal, et al.
Publicado: (2019)

Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications
por: McGorman, Bríonna, et al.
Publicado: (2022)

CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids
por: Yang, Hui, et al.
Publicado: (2023)

AID–RNA polymerase II transcription-dependent deamination of IgV DNA
por: Pham, Phuong, et al.
Publicado: (2019)

Enzymatic synthesis of hypermodified DNA polymers for sequence-specific display of four different hydrophobic groups
por: Ondruš, Marek, et al.
Publicado: (2020)

Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts
por: Gusti Ngurah Putu, Eka Putra, et al.
Publicado: (2023)

Superanionic DNA: enzymatic synthesis of hypermodified DNA bearing four different anionic substituents at all four nucleobases
por: Kuprikova, Natalia, et al.
Publicado: (2023)

Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches
por: Launer-Felty, Katherine D, et al.
Publicado: (2018)

Triplex-forming properties and enzymatic incorporation of a base-modified nucleotide capable of duplex DNA recognition at neutral pH
por: Rusling, David A
Publicado: (2021)

Epigenetic modification of cytosines fine tunes the stability of i-motif DNA
por: Wright, Elisé P, et al.
Publicado: (2020)

Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G
por: Wijesinghe, Priyanga, et al.
Publicado: (2012)

Cytosine epigenetic modification modulates the formation of an unprecedented G4 structure in the WNT1 promoter
por: Wang, Zi-Fu, et al.
Publicado: (2020)

The 3′–5′ proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases
por: Russell, Henry J., et al.
Publicado: (2009)

Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids
por: Yamaguchi, Takao, et al.
Publicado: (2023)

The human methyltransferase ZCCHC4 catalyses N(6)-methyladenosine modification of 28S ribosomal RNA
por: Pinto, Rita, et al.
Publicado: (2020)

Base pairing, structural and functional insights into N(4)-methylcytidine (m(4)C) and N(4),N(4)-dimethylcytidine (m(4)(2)C) modified RNA
por: Mao, Song, et al.
Publicado: (2020)

Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
por: Wolk, Steven K., et al.
Publicado: (2015)

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases
por: Renders, Marleen, et al.
Publicado: (2019)

DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates
por: Lelyveld, Victor S, et al.
Publicado: (2019)

Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism
por: Demir, Merve, et al.
Publicado: (2023)

Intermolecular ‘cross-torque’: the N(4)-cytosine propargyl residue is rotated to the ‘CH’-edge as a result of Watson–Crick interaction
por: Domingo, Olwen, et al.
Publicado: (2015)

Ball with hair: modular functionalization of highly stable G-quadruplex DNA nano-scaffolds through N2-guanine modification
por: Lech, Christopher Jacques, et al.
Publicado: (2017)

Using NMR and molecular dynamics to link structure and dynamics effects of the universal base 8-aza, 7-deaza, N8 linked adenosine analog
por: Spring-Connell, Alexander M., et al.
Publicado: (2016)

7,8-Dihydro-8-oxo-1,N(6)-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli
por: Aralov, Andrey V, et al.
Publicado: (2022)

Selective targeting of parallel G-quadruplex structure using L-RNA aptamer
por: Ji, Danyang, et al.
Publicado: (2023)

Human TDP1, APE1 and TREX1 repair 3′-DNA–peptide/protein cross-links arising from abasic sites in vitro
por: Wei, Xiaoying, et al.
Publicado: (2022)

Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe
por: Zhai, Qianqian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ib3mopp3ogsk96euto31kjqj43