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Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases

Type III CRISPR-Cas effector systems detect foreign RNA triggering DNA and RNA cleavage and synthesizing cyclic oligoadenylate molecules (cA) in their Cas10 subunit. cAs act as a second messenger activating auxiliary nucleases, leading to an indiscriminate RNA degradation that can end in cell dorman...

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Detalles Bibliográficos
Autores principales:	Molina, Rafael, Jensen, Anne Louise Grøn, Marchena-Hurtado, Javier, López-Méndez, Blanca, Stella, Stefano, Montoya, Guillermo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643638/ https://www.ncbi.nlm.nih.gov/pubmed/34850143 http://dx.doi.org/10.1093/nar/gkab1130

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