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7′,5′-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy

Antisense oligonucleotides are small pieces of modified DNA or RNA, which offer therapeutic potential for many diseases. We report on the synthesis of 7′,5′-α-bc-DNA phosphoramidite building blocks, bearing the A, G, T and (Me)C nucleobases. Solid-phase synthesis was performed to construct five olig...

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Detalles Bibliográficos
Autores principales:	Evéquoz, Damien, Verhaart, Ingrid E C, van de Vijver, Davy, Renner, Wolfgang, Aartsma-Rus, Annemieke, Leumann, Christian J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643641/ https://www.ncbi.nlm.nih.gov/pubmed/34850138 http://dx.doi.org/10.1093/nar/gkab1097

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