1088. A Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment of Coronavirus Disease (COVID-19)

BACKGROUND: ADG20 is a fully human IgG1 monoclonal antibody engineered to have potent and broad neutralization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-like CoVs with pandemic potential and an extended half-life. ADG20 is administered intramuscularly (IM)....

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Detalles Bibliográficos
Autores principales: Tarbell, Evan D, Van Wart, Scott A, Shah, Dhaval K, Walker, Laura M, Santulli, Andrew, Connolly, Lynn E, Mager, Donald E, Brown, Ashley N, Ambrose, Paul G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643832/
http://dx.doi.org/10.1093/ofid/ofab466.1282

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