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Anti-tumor efficacy of an MMAE-conjugated antibody targeting cell surface TACE/ADAM17-cleaved Amphiregulin in breast cancer

BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) ligand, Amphiregulin (AREG), is a key proliferative effector of estrogen receptor signaling in breast cancer and also plays a role in other malignancies. AREG is a single-pass transmembrane protein proteolytically processed by TACE/ADAM17 to re...

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Detalles Bibliográficos
Autores principales:	Lofgren, Kristopher A, Sreekumar, Sreeja, Jenkins Jr, E Charles, Ernzen, Kyle J, Kenny, Paraic A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8643873/ https://www.ncbi.nlm.nih.gov/pubmed/34877472 http://dx.doi.org/10.1093/abt/tbab026

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