1286. Taniborbactam Inhibits Cefepime-Hydrolyzing Variants of Pseudomonas-derived Cephalosporinase (PDC)

BACKGROUND: PDC is a class C β-lactamase in P. aeruginosa. PDC-88 is a variant characterized by a Thr-Pro amino acid deletion in the R2-loop (Δ289-290; Fig. 1). This deletion reduces susceptibility to cefepime (FEP), ceftazidime (CAZ), and ceftolozane-tazobactam (TOL/TZB), but the mechanism for this...

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Detalles Bibliográficos
Autores principales: Mack, Andrew R, Bethel, Christopher, Taracilla, Magdalena A, van den Akker, Focco, Miller, Brittany A, Uehara, Tsuyoshi, Six, David A, Papp-Wallace, Krisztina M, Bonomo, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8644514/
http://dx.doi.org/10.1093/ofid/ofab466.1478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8644514/
http://dx.doi.org/10.1093/ofid/ofab466.1478

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