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Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects
BACKGROUND: The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might include some nuclear transport genes in Drosophil...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645118/ https://www.ncbi.nlm.nih.gov/pubmed/34863092 http://dx.doi.org/10.1186/s12864-021-08170-4 |
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author | Mirsalehi, Ayda Markova, Dragomira N. Eslamieh, Mohammadmehdi Betrán, Esther |
author_facet | Mirsalehi, Ayda Markova, Dragomira N. Eslamieh, Mohammadmehdi Betrán, Esther |
author_sort | Mirsalehi, Ayda |
collection | PubMed |
description | BACKGROUND: The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might include some nuclear transport genes in Drosophila. So, using a comprehensive, detailed phylogenomic study, we examined 51 insect genomes for the duplication of the same nuclear transport genes. RESULTS: We find that most of the nuclear transport duplications in Drosophila are of a few classes of nuclear transport genes, RNA mediated and fast evolving. We also retrieve many pseudogenes for the Ran gene. Some of the duplicates are relatively young and likely contributing to the turnover expected for genes under strong but changing selective pressures. These duplications are potentially revealing what features of nuclear transport are under selection. Unlike in flies, we find only a few duplications when we study the Drosophila duplicated nuclear transport genes in dipteran species outside of Drosophila, and none in other insects. CONCLUSIONS: These findings strengthen the hypothesis that nuclear transport gene duplicates in Drosophila evolve either as drivers or suppressors of meiotic drive systems or as other male-specific adaptations circumscribed to flies and involving a handful of nuclear transport functions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12864-021-08170-4. |
format | Online Article Text |
id | pubmed-8645118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-86451182021-12-06 Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects Mirsalehi, Ayda Markova, Dragomira N. Eslamieh, Mohammadmehdi Betrán, Esther BMC Genomics Research BACKGROUND: The nuclear transport machinery is involved in a well-known male meiotic drive system in Drosophila. Fast gene evolution and gene duplications have been major underlying mechanisms in the evolution of meiotic drive systems, and this might include some nuclear transport genes in Drosophila. So, using a comprehensive, detailed phylogenomic study, we examined 51 insect genomes for the duplication of the same nuclear transport genes. RESULTS: We find that most of the nuclear transport duplications in Drosophila are of a few classes of nuclear transport genes, RNA mediated and fast evolving. We also retrieve many pseudogenes for the Ran gene. Some of the duplicates are relatively young and likely contributing to the turnover expected for genes under strong but changing selective pressures. These duplications are potentially revealing what features of nuclear transport are under selection. Unlike in flies, we find only a few duplications when we study the Drosophila duplicated nuclear transport genes in dipteran species outside of Drosophila, and none in other insects. CONCLUSIONS: These findings strengthen the hypothesis that nuclear transport gene duplicates in Drosophila evolve either as drivers or suppressors of meiotic drive systems or as other male-specific adaptations circumscribed to flies and involving a handful of nuclear transport functions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12864-021-08170-4. BioMed Central 2021-12-05 /pmc/articles/PMC8645118/ /pubmed/34863092 http://dx.doi.org/10.1186/s12864-021-08170-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mirsalehi, Ayda Markova, Dragomira N. Eslamieh, Mohammadmehdi Betrán, Esther Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects |
title | Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects |
title_full | Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects |
title_fullStr | Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects |
title_full_unstemmed | Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects |
title_short | Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects |
title_sort | nuclear transport genes recurrently duplicate by means of rna intermediates in drosophila but not in other insects |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645118/ https://www.ncbi.nlm.nih.gov/pubmed/34863092 http://dx.doi.org/10.1186/s12864-021-08170-4 |
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