Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1

Diverse genes associated with familial Parkinson's disease (familial Parkinsonism) have been implicated in mitochondrial quality control. One such gene, PARK7 encodes the protein DJ-1, pathogenic mutations of which trigger its translocation from the cytosol to the mitochondrial matrix. The tran...

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Detalles Bibliográficos
Autores principales: Queliconi, Bruno Barros, Kojima, Waka, Kimura, Mayumi, Imai, Kenichiro, Udagawa, Chisato, Motono, Chie, Hirokawa, Takatsugu, Tashiro, Shinya, Caaveiro, Jose M. M., Tsumoto, Kouhei, Yamano, Koji, Tanaka, Keiji, Matsuda, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645234/
https://www.ncbi.nlm.nih.gov/pubmed/34676411
http://dx.doi.org/10.1242/jcs.258653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645234/
https://www.ncbi.nlm.nih.gov/pubmed/34676411
http://dx.doi.org/10.1242/jcs.258653

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