IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts

OBJECTIVES: Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with activation of human dermal fibroblasts (HDFs) from patients with SSc or controls. METHODS: We measured serum IL...

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Detalles Bibliográficos
Autores principales: Adami, Eleonora, Viswanathan, Sivakumar, Widjaja, Anissa A, Ng, Benjamin, Chothani, Sonia, Zhihao, Nevin, Tan, Jessie, Lio, Pei Min, George, Benjamin L, Altunoglu, Umut, Ghosh, Kakaly, Paleja, Bhairav S, Schafer, Sebastian, Reversade, Bruno, Albani, Salvatore, Ling, Andrea Low Hsiu, O'Reilly, Steven, Cook, Stuart A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645270/
https://www.ncbi.nlm.nih.gov/pubmed/33590875
http://dx.doi.org/10.1093/rheumatology/keab168

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