Cargando…

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma

The clinical outcome of SARS-CoV-2 infections, which can range from asymptomatic to lethal, is crucially shaped by the concentration of antiviral antibodies and by their affinity to their targets. However, the affinity of polyclonal antibody responses in plasma is difficult to measure. Here we used...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schneider, Matthias M, Emmenegger, Marc, Xu, Catherine K, Condado Morales, Itzel, Meisl, Georg, Turelli, Priscilla, Zografou, Chryssa, Zimmermann, Manuela R, Frey, Beat M, Fiedler, Sebastian, Denninger, Viola, Jacquat, Raphaël PB, Madrigal, Lidia, Ilsley, Alison, Kosmoliaptsis, Vasilis, Fiegler, Heike, Trono, Didier, Knowles, Tuomas PJ, Aguzzi, Adriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645332/ https://www.ncbi.nlm.nih.gov/pubmed/34848436 http://dx.doi.org/10.26508/lsa.202101270

Ejemplares similares

Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
por: Fiedler, Sebastian, et al.
Publicado: (2022)

Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants
por: Emmenegger, Marc, et al.
Publicado: (2022)

Protocol to determine antibody affinity and concentration in complex solutions using microfluidic antibody affinity profiling
por: Emmenegger, Marc, et al.
Publicado: (2023)

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region
por: Emmenegger, Marc, et al.
Publicado: (2023)

Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease
por: Meisl, Georg, et al.
Publicado: (2022)

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
por: Meisl, Georg, et al.
Publicado: (2016)

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation
por: Yates, Emma V., et al.
Publicado: (2016)

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants
por: Meisl, Georg, et al.
Publicado: (2017)

The integrase interactor 1 (INI1) proteins facilitate Tat-mediated human immunodeficiency virus type 1 transcription
por: Ariumi, Yasuo, et al.
Publicado: (2006)

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
por: Yang, Xiaoting, et al.
Publicado: (2018)

The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
por: Thacker, Dev, et al.
Publicado: (2020)

Microscale Diffusiophoresis of Proteins
por: Peter, Quentin A. E., et al.
Publicado: (2022)

Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5α
por: Maillard, Pierre V, et al.
Publicado: (2007)

Scaling behaviour and rate-determining steps in filamentous self-assembly
por: Meisl, Georg, et al.
Publicado: (2017)

Absolute Quantification of Amyloid Propagons by Digital Microfluidics
por: Pfammatter, Manuela, et al.
Publicado: (2017)

Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naïve embryonic stem cells
por: Coluccio, Andrea, et al.
Publicado: (2018)

Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction
por: Kothari, Manish S, et al.
Publicado: (2005)

Assessment of human leukocyte antigen immunogenicity: current methods, challenges and opportunities
por: Copley, Hannah C., et al.
Publicado: (2018)

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution
por: Taylor, Christopher G., et al.
Publicado: (2018)

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans
por: Sinnige, Tessa, et al.
Publicado: (2021)

Influence of denaturants on amyloid β42 aggregation kinetics
por: Weiffert, Tanja, et al.
Publicado: (2022)

Oligomer Diversity during the Aggregation of the Repeat Region of Tau
por: Kjaergaard, Magnus, et al.
Publicado: (2018)

The catalytic nature of protein aggregation
por: Dear, Alexander J., et al.
Publicado: (2020)

A Simple Technique for Safe Mesenteric Defect Closure Following Bowel Resection
por: Al Abed, Yahya A., et al.
Publicado: (2012)

Ethylene Glycol Poisoning Should Not Contraindicate Liver Donation
por: Burman, Alisha, et al.
Publicado: (2017)

The Aβ40 and Aβ42 peptides self-assemble into separate homomolecular fibrils in binary mixtures but cross-react during primary nucleation
por: Cukalevski, Risto, et al.
Publicado: (2015)

Identification of on- and off-pathway oligomers in amyloid fibril formation
por: Dear, Alexander J., et al.
Publicado: (2020)

FACT plays a major role in histone dynamics affecting VSG expression site control in Trypanosoma brucei
por: Denninger, Viola, et al.
Publicado: (2014)

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion
por: Zhang, Yuewen, et al.
Publicado: (2018)

Influence of HLA Class II Polymorphism on Predicted Cellular Immunity Against SARS-CoV-2 at the Population and Individual Level
por: Copley, Hannah C., et al.
Publicado: (2021)

Editorial: Future challenges and directions in determining allo-immunity in kidney transplantation
por: Lim, Wai H., et al.
Publicado: (2022)

Direct Observation of Murine Prion Protein Replication in Vitro
por: Sang, Jason C., et al.
Publicado: (2018)

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils
por: Törnquist, Mattias, et al.
Publicado: (2020)

Effects of sedimentation, microgravity, hydrodynamic mixing and air–water interface on α-synuclein amyloid formation
por: Zhou, Jiangtao, et al.
Publicado: (2020)

A flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle
por: Davey, Karen, et al.
Publicado: (2021)

Physical determinants of the self-replication of protein fibrils
por: Šarić, Anđela, et al.
Publicado: (2016)

A Comparison of HLA Molecular Mismatch Methods to Determine HLA Immunogenicity
por: Wiebe, Chris, et al.
Publicado: (2018)

Arquitectura viva: Proyecto de Museo de Sitio para la generación de espacios autosuficientes en la zona arqueológica de “Los Teteles” Teocelo, Ver.
por: Madrigal Herrera, Alicia Itzel
Publicado: (2019)

Ultrasonography of the reticulum in 30 healthy Saanen goats
por: Braun, Ueli, et al.
Publicado: (2011)

Ultrasonography of the omasum in 30 Saanen goats
por: Braun, Ueli, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_l29bdvtth7rv1hra2bes0omamm