ALKBH5 Is Lowly Expressed in Esophageal Squamous Cell Carcinoma and Inhibits the Malignant Proliferation and Invasion of Tumor Cells

BACKGROUND: Modification of N(6)-methyladenosine (m(6)A) and RNA m(6)A regulatory factors is required in cancer advancement. The contribution of m(6)A and its alteration in esophageal squamous cell carcinoma (ESCC) is still unclear. RESULTS: ALKBH5 was lowly expressed in ESCC tissues, which the tota...

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Detalles Bibliográficos
Autores principales: Li, Jinqiu, Liu, Hongqiang, Dong, Shanglin, Zhang, Yunbo, Li, Xiao, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645391/
https://www.ncbi.nlm.nih.gov/pubmed/34876920
http://dx.doi.org/10.1155/2021/1001446
Descripción
Sumario:BACKGROUND: Modification of N(6)-methyladenosine (m(6)A) and RNA m(6)A regulatory factors is required in cancer advancement. The contribution of m(6)A and its alteration in esophageal squamous cell carcinoma (ESCC) is still unclear. RESULTS: ALKBH5 was lowly expressed in ESCC tissues, which the total m(6)A level was increased in ESCC tissue than the presentation in normal healthy tissue. The pcDNA3.1-ALKBH5 recombinant plasmid was transfected into KYSE-150 and Eca-109 cells. The overexpression of ALKBH5 is responsible for a significant reduction of the total m(6)A levels in Eca-109 and KYSE150 cells, inhibiting the proliferation capability, migration, and cell invasion. CONCLUSIONS: ALKBH5 as a demethylase was lowly expressed in cancer progression of ESCC and acts as a crucial component in ESCC progression.

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