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A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules

Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used tr...

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Autores principales: Kumadoh, Doris, Archer, Mary-Ann, Yeboah, Genevieve N., Kyene, Michael O., Boakye-Yiadom, Mavis, Adi-Dako, Ofosua, Osei-Asare, Christina, Adase, Emmanuel, Appiah, Alfred A., Mintah, Susana O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645450/
https://www.ncbi.nlm.nih.gov/pubmed/34917789
http://dx.doi.org/10.1016/j.heliyon.2021.e08465
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author Kumadoh, Doris
Archer, Mary-Ann
Yeboah, Genevieve N.
Kyene, Michael O.
Boakye-Yiadom, Mavis
Adi-Dako, Ofosua
Osei-Asare, Christina
Adase, Emmanuel
Appiah, Alfred A.
Mintah, Susana O.
author_facet Kumadoh, Doris
Archer, Mary-Ann
Yeboah, Genevieve N.
Kyene, Michael O.
Boakye-Yiadom, Mavis
Adi-Dako, Ofosua
Osei-Asare, Christina
Adase, Emmanuel
Appiah, Alfred A.
Mintah, Susana O.
author_sort Kumadoh, Doris
collection PubMed
description Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and in-vitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. METHODS: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. RESULTS: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. INTERPRETATION: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD.
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spelling pubmed-86454502021-12-15 A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules Kumadoh, Doris Archer, Mary-Ann Yeboah, Genevieve N. Kyene, Michael O. Boakye-Yiadom, Mavis Adi-Dako, Ofosua Osei-Asare, Christina Adase, Emmanuel Appiah, Alfred A. Mintah, Susana O. Heliyon Review Article Peptic ulcer disease affects many people globally. With the increasing resistance to some orthodox antibiotics such as Clarithromycin and Metronidazole, it is important that new acceptable, safer and effective therapies are developed to manage this disease. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and in-vitro as well as clinical studies supporting their use is still inadequate. The Centre for Plant Medicine Research, (CPMR) Mampong-Akuapem, Ghana manufactures three herbal Products namely Enterica, Dyspepsia and NPK 500 capsules which are currently used for the remedy of PUD as a triple therapy at its out-patient clinic with promising effects. The aim of this review is to gather information from literature on the anti-ulcer properties, pharmacological, phytochemical constituents and related activities of herbal plants used at the CPMR for formulation of the triple herbal therapy. This review may, provide some scientific bases for the use of Enterica, Dyspepsia and NPK 500 capsules in the management of Peptic ulcer at the CPMR out-patient clinic. METHODS: Organization for the review involved the on and/or offline search for information from available literature using electronic data and scientific research information resources such as PubMed, Science Direct and Google scholar. RESULTS: In this review, fifteen ethno-medicinal plants used for the formulation of Enterica, Dyspepsia and NPK capsules have been discussed, presenting the description of the plants, composition and pharmacological activity. INTERPRETATION: Tables with the summary of reviewed medicinal plants with their anti-ulcer models and inference on possible mechanisms of action were drawn up. The mechanism(s) of action of individual plants and products (Enterica, Dyspepsia and NPK 500 capsules) must be further investigated and established experimentally in-vitro in addition to in-vivo pharmacological and clinical activity studies to confirm their use in the remedy of PUD. Elsevier 2021-11-29 /pmc/articles/PMC8645450/ /pubmed/34917789 http://dx.doi.org/10.1016/j.heliyon.2021.e08465 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Kumadoh, Doris
Archer, Mary-Ann
Yeboah, Genevieve N.
Kyene, Michael O.
Boakye-Yiadom, Mavis
Adi-Dako, Ofosua
Osei-Asare, Christina
Adase, Emmanuel
Appiah, Alfred A.
Mintah, Susana O.
A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_full A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_fullStr A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_full_unstemmed A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_short A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules
title_sort review on anti-peptic ulcer activities of medicinal plants used in the formulation of enterica, dyspepsia and npk 500 capsules
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645450/
https://www.ncbi.nlm.nih.gov/pubmed/34917789
http://dx.doi.org/10.1016/j.heliyon.2021.e08465
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