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Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study
BACKGROUND: Severe acute respiratory syndrome corona virus 2(SARS-CoV-2), the causative agent of corona virus disease-2019(COVID- 19) which has led to a global pandemic. The true extent of the burden of COVID-19 may be underestimated, and there is need to know the current prevalence of SARS-CoV-2 an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645505/ https://www.ncbi.nlm.nih.gov/pubmed/34933819 http://dx.doi.org/10.1016/j.transci.2021.103338 |
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author | Jaiswal, Ram Sharma, Shweta Singla, Ashina Devpura, Nimisha Vohra, Rajat Kakkar, Munish Rijhwani, Puneet Sureka, Rajendra |
author_facet | Jaiswal, Ram Sharma, Shweta Singla, Ashina Devpura, Nimisha Vohra, Rajat Kakkar, Munish Rijhwani, Puneet Sureka, Rajendra |
author_sort | Jaiswal, Ram |
collection | PubMed |
description | BACKGROUND: Severe acute respiratory syndrome corona virus 2(SARS-CoV-2), the causative agent of corona virus disease-2019(COVID- 19) which has led to a global pandemic. The true extent of the burden of COVID-19 may be underestimated, and there is need to know the current prevalence of SARS-CoV-2 antibody in population. METHODS: The present study was a cross-sectional study to assess prevalence of SARS-CoV- 2 IgG antibody among 586 healthy voluntary blood donors who donated whole blood between mid-December 2020 to January 2021. A chemiluminescence assay was used to detect the presence of SARS-CoV-2 IgG antibody in serum samples in addition to recommended transfusion transmitted infections tests and Signal to Cut Off (S/C) > 1 was considered as reactive for antibody as per manufacturer’s instructions. RESULTS: In the present study, 586 healthy voluntary blood donors were enrolled and were screened for SARS- CoV-2 IgG antibody. Out of 586 donors, 52 donors had indeterminate values of SARS-CoV-2 IgG antibody. A total of 534 healthy voluntary blood donors’ samples were included in the present study for analysis. Out of total 534 healthy blood donors, 42.88% (229) were found to be seropositive while 57.11% (305) were found to be seronegative. CONCLUSION: A 43% positivity of SARS-CoV-2 IgG antibody among healthy blood donors was detected which is an indication of presence of infection at community level and majority of the population already has been exposed to SARS-CoV-2 infection. However, there was no statistically significant association of type of blood group and age with seropositivity. |
format | Online Article Text |
id | pubmed-8645505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86455052021-12-06 Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study Jaiswal, Ram Sharma, Shweta Singla, Ashina Devpura, Nimisha Vohra, Rajat Kakkar, Munish Rijhwani, Puneet Sureka, Rajendra Transfus Apher Sci Article BACKGROUND: Severe acute respiratory syndrome corona virus 2(SARS-CoV-2), the causative agent of corona virus disease-2019(COVID- 19) which has led to a global pandemic. The true extent of the burden of COVID-19 may be underestimated, and there is need to know the current prevalence of SARS-CoV-2 antibody in population. METHODS: The present study was a cross-sectional study to assess prevalence of SARS-CoV- 2 IgG antibody among 586 healthy voluntary blood donors who donated whole blood between mid-December 2020 to January 2021. A chemiluminescence assay was used to detect the presence of SARS-CoV-2 IgG antibody in serum samples in addition to recommended transfusion transmitted infections tests and Signal to Cut Off (S/C) > 1 was considered as reactive for antibody as per manufacturer’s instructions. RESULTS: In the present study, 586 healthy voluntary blood donors were enrolled and were screened for SARS- CoV-2 IgG antibody. Out of 586 donors, 52 donors had indeterminate values of SARS-CoV-2 IgG antibody. A total of 534 healthy voluntary blood donors’ samples were included in the present study for analysis. Out of total 534 healthy blood donors, 42.88% (229) were found to be seropositive while 57.11% (305) were found to be seronegative. CONCLUSION: A 43% positivity of SARS-CoV-2 IgG antibody among healthy blood donors was detected which is an indication of presence of infection at community level and majority of the population already has been exposed to SARS-CoV-2 infection. However, there was no statistically significant association of type of blood group and age with seropositivity. Elsevier Ltd. 2022-06 2021-12-06 /pmc/articles/PMC8645505/ /pubmed/34933819 http://dx.doi.org/10.1016/j.transci.2021.103338 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Jaiswal, Ram Sharma, Shweta Singla, Ashina Devpura, Nimisha Vohra, Rajat Kakkar, Munish Rijhwani, Puneet Sureka, Rajendra Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study |
title | Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study |
title_full | Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study |
title_fullStr | Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study |
title_full_unstemmed | Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study |
title_short | Seroprevalence of SARS-CoV-2 IgG antibody among healthy blood donors: a single centre study |
title_sort | seroprevalence of sars-cov-2 igg antibody among healthy blood donors: a single centre study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645505/ https://www.ncbi.nlm.nih.gov/pubmed/34933819 http://dx.doi.org/10.1016/j.transci.2021.103338 |
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