Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome

We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after...

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Autores principales: Braun, Tobias, Viard, Maxime, Juenemann, Martin, Struffert, Tobias, Schwarm, Frank, Huttner, Hagen B., Roessler, Florian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645635/
https://www.ncbi.nlm.nih.gov/pubmed/34880826
http://dx.doi.org/10.3389/fneur.2021.763049
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author Braun, Tobias
Viard, Maxime
Juenemann, Martin
Struffert, Tobias
Schwarm, Frank
Huttner, Hagen B.
Roessler, Florian C.
author_facet Braun, Tobias
Viard, Maxime
Juenemann, Martin
Struffert, Tobias
Schwarm, Frank
Huttner, Hagen B.
Roessler, Florian C.
author_sort Braun, Tobias
collection PubMed
description We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after the onset of the symptom, the first MR-angiography provided no evidence of CVST. Follow-up imaging, performed upon headache refractory to nonsteroidal pain medication verified CVST 2–10 days after initial negative MRI. Both the patients received combined treatment with intravenous immunoglobulins and parenteral anticoagulation leading to an increase of platelet concentration in both the individuals and resolution of the occluded cerebral sinus in one patient.
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spelling pubmed-86456352021-12-07 Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome Braun, Tobias Viard, Maxime Juenemann, Martin Struffert, Tobias Schwarm, Frank Huttner, Hagen B. Roessler, Florian C. Front Neurol Neurology We present two cases of ChAdOx1 nCov-19 (AstraZeneca)-associated thrombotic thrombocytopenia syndrome (TTS) and cerebral venous sinus thrombosis (CVST). At the time of emergency room presentation due to persistent headache, blood serum levels revealed reduced platelet counts. Yet, 1 or 4 days after the onset of the symptom, the first MR-angiography provided no evidence of CVST. Follow-up imaging, performed upon headache refractory to nonsteroidal pain medication verified CVST 2–10 days after initial negative MRI. Both the patients received combined treatment with intravenous immunoglobulins and parenteral anticoagulation leading to an increase of platelet concentration in both the individuals and resolution of the occluded cerebral sinus in one patient. Frontiers Media S.A. 2021-11-22 /pmc/articles/PMC8645635/ /pubmed/34880826 http://dx.doi.org/10.3389/fneur.2021.763049 Text en Copyright © 2021 Braun, Viard, Juenemann, Struffert, Schwarm, Huttner and Roessler. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Braun, Tobias
Viard, Maxime
Juenemann, Martin
Struffert, Tobias
Schwarm, Frank
Huttner, Hagen B.
Roessler, Florian C.
Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_full Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_fullStr Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_full_unstemmed Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_short Case Report: Take a Second Look: Covid-19 Vaccination-Related Cerebral Venous Thrombosis and Thrombotic Thrombocytopenia Syndrome
title_sort case report: take a second look: covid-19 vaccination-related cerebral venous thrombosis and thrombotic thrombocytopenia syndrome
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645635/
https://www.ncbi.nlm.nih.gov/pubmed/34880826
http://dx.doi.org/10.3389/fneur.2021.763049
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