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Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib

Aim: Apatinib is an orally administered vascular epidermal growth factor receptor (VEGFR)-tyrosine kinase inhibitors approved for the treatment of advanced gastric adenocarcinoma or gastric esophageal junction adenocarcinoma. Apatinib is predominantly metabolized by CYP3A4/5, followed by CYP2D6. The...

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Detalles Bibliográficos
Autores principales:	Liu, Hongrui, Yu, Yiqun, Guo, Nan, Wang, Xiaojuan, Han, Bing, Xiang, Xiaoqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645681/ https://www.ncbi.nlm.nih.gov/pubmed/34880763 http://dx.doi.org/10.3389/fphar.2021.780937

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