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Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol

Hypercholesterolemia is the main cause of cardiovascular disease worldwide, and the regulation of cholesterol homeostasis is essential for human health. Lactobacillus is present in large quantities in the human intestine. As the normal flora in the gut, lactobacillus plays an important role in regul...

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Detalles Bibliográficos
Autores principales: Cao, Kaihui, Zhang, Kaiping, Ma, Muran, Ma, Junjie, Tian, Jianjun, Jin, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645708/
https://www.ncbi.nlm.nih.gov/pubmed/34925816
http://dx.doi.org/10.1002/fsn3.2600
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author Cao, Kaihui
Zhang, Kaiping
Ma, Muran
Ma, Junjie
Tian, Jianjun
Jin, Ye
author_facet Cao, Kaihui
Zhang, Kaiping
Ma, Muran
Ma, Junjie
Tian, Jianjun
Jin, Ye
author_sort Cao, Kaihui
collection PubMed
description Hypercholesterolemia is the main cause of cardiovascular disease worldwide, and the regulation of cholesterol homeostasis is essential for human health. Lactobacillus is present in large quantities in the human intestine. As the normal flora in the gut, lactobacillus plays an important role in regulating metabolism in the human body. Lactobacillus can regulate the cholesterol content by regulating the expression of genes involved in cholesterol synthesis, metabolism, and absorption. This article reviews the biological effects and mechanisms of lactobacillus that mediate the expression of NPC1L1, CYP7A1, ABCG5, ABCG8, and other genes to inhibit cholesterol absorption, and discusses the mechanism of reducing cholesterol by lactobacillus in cells in vitro, to provide a theoretical basis for the development and utilization of lactobacillus resources.
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spelling pubmed-86457082021-12-17 Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol Cao, Kaihui Zhang, Kaiping Ma, Muran Ma, Junjie Tian, Jianjun Jin, Ye Food Sci Nutr Reviews Hypercholesterolemia is the main cause of cardiovascular disease worldwide, and the regulation of cholesterol homeostasis is essential for human health. Lactobacillus is present in large quantities in the human intestine. As the normal flora in the gut, lactobacillus plays an important role in regulating metabolism in the human body. Lactobacillus can regulate the cholesterol content by regulating the expression of genes involved in cholesterol synthesis, metabolism, and absorption. This article reviews the biological effects and mechanisms of lactobacillus that mediate the expression of NPC1L1, CYP7A1, ABCG5, ABCG8, and other genes to inhibit cholesterol absorption, and discusses the mechanism of reducing cholesterol by lactobacillus in cells in vitro, to provide a theoretical basis for the development and utilization of lactobacillus resources. John Wiley and Sons Inc. 2021-09-30 /pmc/articles/PMC8645708/ /pubmed/34925816 http://dx.doi.org/10.1002/fsn3.2600 Text en © 2021 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Cao, Kaihui
Zhang, Kaiping
Ma, Muran
Ma, Junjie
Tian, Jianjun
Jin, Ye
Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
title Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
title_full Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
title_fullStr Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
title_full_unstemmed Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
title_short Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol
title_sort lactobacillus mediates the expression of npc1l1, cyp7a1, and abcg5 genes to regulate cholesterol
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645708/
https://www.ncbi.nlm.nih.gov/pubmed/34925816
http://dx.doi.org/10.1002/fsn3.2600
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