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Oligomerization of Mutant p53 R273H is not Required for Gain-of-Function Chromatin Associated Activities
The TP53 gene is often mutated in cancer, with missense mutations found in the central DNA binding domain, and less often in the C-terminal oligomerization domain (OD). These types of mutations are found in patients with the rare inherited cancer predisposition disorder called Li-Fraumeni syndrome....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645790/ https://www.ncbi.nlm.nih.gov/pubmed/34881245 http://dx.doi.org/10.3389/fcell.2021.772315 |