Cargando…

Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review

Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored the efficacy and safety of applying chlorpromazine on PMC pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, James Jiqi, He, Zuowen, Yang, Yan, Yu, Bo, Wang, Hong, Ding, Hu, Cui, Guanglin, Wang, Luyun, Wang, Dao Wen, Jiang, Jiangang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645834/
https://www.ncbi.nlm.nih.gov/pubmed/34881311
http://dx.doi.org/10.3389/fcvm.2021.762371
_version_ 1784610392225349632
author Wang, James Jiqi
He, Zuowen
Yang, Yan
Yu, Bo
Wang, Hong
Ding, Hu
Cui, Guanglin
Wang, Luyun
Wang, Dao Wen
Jiang, Jiangang
author_facet Wang, James Jiqi
He, Zuowen
Yang, Yan
Yu, Bo
Wang, Hong
Ding, Hu
Cui, Guanglin
Wang, Luyun
Wang, Dao Wen
Jiang, Jiangang
author_sort Wang, James Jiqi
collection PubMed
description Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored the efficacy and safety of applying chlorpromazine on PMC patients. The study included seven patients (median age, 42 years; range, 14–57 years) diagnosed with pheochromocytoma. Four consecutive PMC patients were admitted to our critical care unit between 2016 and 2020 due to abdominal or waist pain, nausea, and vomiting. Their blood pressure (BP) fluctuated between 200–330/120–200 and 40–70/30–50 mmHg. Chlorpromazine (25 or 50 mg) was injected intramuscularly, followed by continuous intravenous infusion (2–8 mg/h). The patients' BP decreased to 100–150/60–100 mmHg within 1–3 h and stabilized within 3–5 days. Two weeks later, surgical tumor resection was successfully performed in all four patients. Similar clinical outcomes were also obtained in three patients with sporadic PMC reported in the literature who received chlorpromazine treatment, which reduced their BP readings from >200/100 mmHg to 120/70 mmHg. Our observations, combined with sporadic reports, showed that chlorpromazine efficiently controlled PMC. Thus, future studies on the use of chlorpromazine are warranted.
format Online
Article
Text
id pubmed-8645834
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86458342021-12-07 Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review Wang, James Jiqi He, Zuowen Yang, Yan Yu, Bo Wang, Hong Ding, Hu Cui, Guanglin Wang, Luyun Wang, Dao Wen Jiang, Jiangang Front Cardiovasc Med Cardiovascular Medicine Pheochromocytoma multisystem crisis (PMC) is a potentially lethal emergency due to catecholamine secretion. The condition manifests as severe hypertension to intractable cardiogenic shock and has a high mortality rate. This study explored the efficacy and safety of applying chlorpromazine on PMC patients. The study included seven patients (median age, 42 years; range, 14–57 years) diagnosed with pheochromocytoma. Four consecutive PMC patients were admitted to our critical care unit between 2016 and 2020 due to abdominal or waist pain, nausea, and vomiting. Their blood pressure (BP) fluctuated between 200–330/120–200 and 40–70/30–50 mmHg. Chlorpromazine (25 or 50 mg) was injected intramuscularly, followed by continuous intravenous infusion (2–8 mg/h). The patients' BP decreased to 100–150/60–100 mmHg within 1–3 h and stabilized within 3–5 days. Two weeks later, surgical tumor resection was successfully performed in all four patients. Similar clinical outcomes were also obtained in three patients with sporadic PMC reported in the literature who received chlorpromazine treatment, which reduced their BP readings from >200/100 mmHg to 120/70 mmHg. Our observations, combined with sporadic reports, showed that chlorpromazine efficiently controlled PMC. Thus, future studies on the use of chlorpromazine are warranted. Frontiers Media S.A. 2021-11-22 /pmc/articles/PMC8645834/ /pubmed/34881311 http://dx.doi.org/10.3389/fcvm.2021.762371 Text en Copyright © 2021 Wang, He, Yang, Yu, Wang, Ding, Cui, Wang, Wang and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Wang, James Jiqi
He, Zuowen
Yang, Yan
Yu, Bo
Wang, Hong
Ding, Hu
Cui, Guanglin
Wang, Luyun
Wang, Dao Wen
Jiang, Jiangang
Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_full Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_fullStr Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_full_unstemmed Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_short Chlorpromazine Efficiently Treats the Crisis of Pheochromocytoma: Four Case Reports and Literature Review
title_sort chlorpromazine efficiently treats the crisis of pheochromocytoma: four case reports and literature review
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645834/
https://www.ncbi.nlm.nih.gov/pubmed/34881311
http://dx.doi.org/10.3389/fcvm.2021.762371
work_keys_str_mv AT wangjamesjiqi chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT hezuowen chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT yangyan chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT yubo chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT wanghong chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT dinghu chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT cuiguanglin chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT wangluyun chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT wangdaowen chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview
AT jiangjiangang chlorpromazineefficientlytreatsthecrisisofpheochromocytomafourcasereportsandliteraturereview