A Functional Human-on-a-Chip Autoimmune Disease Model of Myasthenia Gravis for Development of Therapeutics

Myasthenia gravis (MG) is a chronic and progressive neuromuscular disease where autoantibodies target essential proteins such as the nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction (NMJ) causing muscle fatigue and weakness. Autoantibodies directed against nAChRs are proposed t...

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Detalles Bibliográficos
Autores principales: Smith, Virginia M., Nguyen, Huan, Rumsey, John W., Long, Christopher J., Shuler, Michael L., Hickman, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645836/
https://www.ncbi.nlm.nih.gov/pubmed/34881241
http://dx.doi.org/10.3389/fcell.2021.745897

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