Cargando…
Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy
Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range unce...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645917/ https://www.ncbi.nlm.nih.gov/pubmed/34917780 http://dx.doi.org/10.1016/j.phro.2021.11.005 |
| _version_ | 1784610411692163072 |
|---|---|
| author | Hofmaier, Jan Walter, Franziska Hadi, Indrawati Rottler, Maya von Bestenbostel, Rieke Dedes, George Parodi, Katia Niyazi, Maximilian Belka, Claus Kamp, Florian |
| author_facet | Hofmaier, Jan Walter, Franziska Hadi, Indrawati Rottler, Maya von Bestenbostel, Rieke Dedes, George Parodi, Katia Niyazi, Maximilian Belka, Claus Kamp, Florian |
| author_sort | Hofmaier, Jan |
| collection | PubMed |
| description | Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 10(4) dose recalculations was 59 min. For two patients in this dataset, IOV had a relevant impact on the estimated CTV D(95%) uncertainty. |
| format | Online Article Text |
| id | pubmed-8645917 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86459172021-12-15 Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy Hofmaier, Jan Walter, Franziska Hadi, Indrawati Rottler, Maya von Bestenbostel, Rieke Dedes, George Parodi, Katia Niyazi, Maximilian Belka, Claus Kamp, Florian Phys Imaging Radiat Oncol Technical Note Margin concepts in proton therapy aim to ensure full dose coverage of the clinical target volume (CTV) in presence of setup and range uncertainty. Due to inter-observer variability (IOV), the CTV itself is uncertain. We present a framework to evaluate the combined impact of IOV, setup and range uncertainty in a variance-based sensitivity analysis (SA). For ten patients with skull base meningioma, the mean calculation time to perform the SA including 1.6 × 10(4) dose recalculations was 59 min. For two patients in this dataset, IOV had a relevant impact on the estimated CTV D(95%) uncertainty. Elsevier 2021-12-02 /pmc/articles/PMC8645917/ /pubmed/34917780 http://dx.doi.org/10.1016/j.phro.2021.11.005 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Technical Note Hofmaier, Jan Walter, Franziska Hadi, Indrawati Rottler, Maya von Bestenbostel, Rieke Dedes, George Parodi, Katia Niyazi, Maximilian Belka, Claus Kamp, Florian Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy |
| title | Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy |
| title_full | Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy |
| title_fullStr | Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy |
| title_full_unstemmed | Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy |
| title_short | Combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy |
| title_sort | combining inter-observer variability, range and setup uncertainty in a variance-based sensitivity analysis for proton therapy |
| topic | Technical Note |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645917/ https://www.ncbi.nlm.nih.gov/pubmed/34917780 http://dx.doi.org/10.1016/j.phro.2021.11.005 |
| work_keys_str_mv | AT hofmaierjan combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT walterfranziska combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT hadiindrawati combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT rottlermaya combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT vonbestenbostelrieke combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT dedesgeorge combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT parodikatia combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT niyazimaximilian combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT belkaclaus combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy AT kampflorian combininginterobservervariabilityrangeandsetupuncertaintyinavariancebasedsensitivityanalysisforprotontherapy |