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Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645932/ https://www.ncbi.nlm.nih.gov/pubmed/34880876 http://dx.doi.org/10.3389/fimmu.2021.783370 |
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author | Xie, Feiling Dong, Hongmei Zhang, Hao |
author_facet | Xie, Feiling Dong, Hongmei Zhang, Hao |
author_sort | Xie, Feiling |
collection | PubMed |
description | The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belongs to the R3 receptor-like protein tyrosine phosphatases. The expression of PTPRO isoforms is tissue-specific and the truncated PTPRO (PTPROt) is mainly observed in hematopoietic cells, including B cells, T cells, macrophages and other immune cells. Therefore, PTPROt may play an important role in immune cells by affecting their growth, differentiation, activation and immune responses. In this review, we will focus on the regulatory roles and underlying molecular mechanisms of PTPRO/PTPROt in immune cells, including B cells, T cells, and macrophages. |
format | Online Article Text |
id | pubmed-8645932 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86459322021-12-07 Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells Xie, Feiling Dong, Hongmei Zhang, Hao Front Immunol Immunology The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response. As a member of PTP family, protein tyrosine phosphatase receptor type O (PTPRO) belongs to the R3 receptor-like protein tyrosine phosphatases. The expression of PTPRO isoforms is tissue-specific and the truncated PTPRO (PTPROt) is mainly observed in hematopoietic cells, including B cells, T cells, macrophages and other immune cells. Therefore, PTPROt may play an important role in immune cells by affecting their growth, differentiation, activation and immune responses. In this review, we will focus on the regulatory roles and underlying molecular mechanisms of PTPRO/PTPROt in immune cells, including B cells, T cells, and macrophages. Frontiers Media S.A. 2021-11-22 /pmc/articles/PMC8645932/ /pubmed/34880876 http://dx.doi.org/10.3389/fimmu.2021.783370 Text en Copyright © 2021 Xie, Dong and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Xie, Feiling Dong, Hongmei Zhang, Hao Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells |
title | Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells |
title_full | Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells |
title_fullStr | Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells |
title_full_unstemmed | Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells |
title_short | Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells |
title_sort | regulatory functions of protein tyrosine phosphatase receptor type o in immune cells |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645932/ https://www.ncbi.nlm.nih.gov/pubmed/34880876 http://dx.doi.org/10.3389/fimmu.2021.783370 |
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