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Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function

Apathy is thought to be an important clinical feature of Parkinson’s disease (PD). However, its prevalence ranges greatly across studies because of differing definitions, assessment tools, and patient inclusion criteria. Furthermore, it remains unclear how the presentation of apathy in PD is related...

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Autores principales: Foley, Jennifer A., Cipolotti, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645993/
https://www.ncbi.nlm.nih.gov/pubmed/34880810
http://dx.doi.org/10.3389/fpsyg.2021.749624
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author Foley, Jennifer A.
Cipolotti, Lisa
author_facet Foley, Jennifer A.
Cipolotti, Lisa
author_sort Foley, Jennifer A.
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description Apathy is thought to be an important clinical feature of Parkinson’s disease (PD). However, its prevalence ranges greatly across studies because of differing definitions, assessment tools, and patient inclusion criteria. Furthermore, it remains unclear how the presentation of apathy in PD is related to mood disorder and/or cognitive impairment. This study sought to examine the prevalence of a pure apathy syndrome in PD, distinct from both depression and anxiety, and reveal its associated cognitive profile. A retrospective study was performed on 177 PD patients who had completed measures of apathy [Apathy Evaluation Scale (AES)] and mood functioning [Hospital Anxiety and Depression Scale (HADS)] and had undergone extensive neuropsychological assessment, using measures of intellectual functioning, memory, executive function, attention, language, visual processing, and cognitive speed; 14.7% of the sample indicated clinically significant levels of apathy, but this nearly always co-presented with depression and/or anxiety, with cases of “pure” apathy very rare (2.8%). On extensive cognitive assessment, patients with mood disorder performed worse on a measure of non-verbal intellectual functioning, but patients with additional apathy or apathy only demonstrated no further losses. The syndrome of apathy in PD greatly overlaps with that of depression and anxiety, suggesting that apathy in PD may be in large an epiphenomenon of mood disorder, with no specific neuropsychological features.
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spelling pubmed-86459932021-12-07 Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function Foley, Jennifer A. Cipolotti, Lisa Front Psychol Psychology Apathy is thought to be an important clinical feature of Parkinson’s disease (PD). However, its prevalence ranges greatly across studies because of differing definitions, assessment tools, and patient inclusion criteria. Furthermore, it remains unclear how the presentation of apathy in PD is related to mood disorder and/or cognitive impairment. This study sought to examine the prevalence of a pure apathy syndrome in PD, distinct from both depression and anxiety, and reveal its associated cognitive profile. A retrospective study was performed on 177 PD patients who had completed measures of apathy [Apathy Evaluation Scale (AES)] and mood functioning [Hospital Anxiety and Depression Scale (HADS)] and had undergone extensive neuropsychological assessment, using measures of intellectual functioning, memory, executive function, attention, language, visual processing, and cognitive speed; 14.7% of the sample indicated clinically significant levels of apathy, but this nearly always co-presented with depression and/or anxiety, with cases of “pure” apathy very rare (2.8%). On extensive cognitive assessment, patients with mood disorder performed worse on a measure of non-verbal intellectual functioning, but patients with additional apathy or apathy only demonstrated no further losses. The syndrome of apathy in PD greatly overlaps with that of depression and anxiety, suggesting that apathy in PD may be in large an epiphenomenon of mood disorder, with no specific neuropsychological features. Frontiers Media S.A. 2021-11-22 /pmc/articles/PMC8645993/ /pubmed/34880810 http://dx.doi.org/10.3389/fpsyg.2021.749624 Text en Copyright © 2021 Foley and Cipolotti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Foley, Jennifer A.
Cipolotti, Lisa
Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function
title Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function
title_full Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function
title_fullStr Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function
title_full_unstemmed Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function
title_short Apathy in Parkinson’s Disease: A Retrospective Study of Its Prevalence and Relationship With Mood, Anxiety, and Cognitive Function
title_sort apathy in parkinson’s disease: a retrospective study of its prevalence and relationship with mood, anxiety, and cognitive function
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645993/
https://www.ncbi.nlm.nih.gov/pubmed/34880810
http://dx.doi.org/10.3389/fpsyg.2021.749624
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