Cargando…

Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis

Idiopathic pulmonary fibrosis is a progressive fatal disease characterized by interstitial remodeling, with high lethality and a lack of effective medical therapies. Tetrandrine has been proposed to present anti-fibrotic effects, but the efficacy and mechanisms have not been systematically evaluated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yuanyuan, Zhong, Wenshan, Zhang, Jinming, Chen, Weimou, lu, Ye, Qiao, Yujie, Zeng, Zhaojin, Huang, Haohua, Cai, Shaoxi, Dong, Hangming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645995/ https://www.ncbi.nlm.nih.gov/pubmed/34880752 http://dx.doi.org/10.3389/fphar.2021.739220

Ejemplares similares

Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis
por: Chen, Weimou, et al.
Publicado: (2021)

Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis
por: Zhang, Jinming, et al.
Publicado: (2021)

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms
por: Wong, Vincent Kam Wai, et al.
Publicado: (2017)

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma
por: Ghosh, Arindam P., et al.
Publicado: (2015)

Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway
por: Li, Shu-xian, et al.
Publicado: (2021)

Number 2 Feibi Recipe Ameliorates Pulmonary Fibrosis by Inducing Autophagy Through the GSK-3β/mTOR Pathway
por: Liu, Haoge, et al.
Publicado: (2022)

Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells
por: Li, Gaopan, et al.
Publicado: (2021)

Glutamine Availability Regulates the Development of Aging Mediated by mTOR Signaling and Autophagy
por: Zhou, Jiao, et al.
Publicado: (2022)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

mTOR-Inhibition and COVID-19 in Kidney Transplant Recipients: Focus on Pulmonary Fibrosis
por: Granata, Simona, et al.
Publicado: (2021)

Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway
por: Liu, Suqing, et al.
Publicado: (2022)

RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity
por: Proietti Onori, Martina, et al.
Publicado: (2021)

mTOR Overactivation and Compromised Autophagy in the Pathogenesis of Pulmonary Fibrosis
por: Gui, Yao-Song, et al.
Publicado: (2015)

Long noncoding RNA BFAL1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal cancer via the RHEB/mTOR pathway
por: Bao, Yujie, et al.
Publicado: (2019)

Resolvin D1 attenuates CCl4 Induced Liver Fibrosis by Inhibiting Autophagy-Mediated HSC activation via AKT/mTOR Pathway
por: Li, Jiahuan, et al.
Publicado: (2021)

Electroacupuncture Upregulated Ghrelin in Rats with Functional Dyspepsia via AMPK/TSC2/Rheb-Mediated mTOR Inhibition
por: Tang, Lei, et al.
Publicado: (2019)

Commentary: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
por: Renna, Maurizio
Publicado: (2016)

Zinc-Doped Copper Oxide Nanocomposites Inhibit the Growth of Pancreatic Cancer by Inducing Autophagy Through AMPK/mTOR Pathway
por: Li, Xiao, et al.
Publicado: (2019)

The mTOR pathway genes mTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
por: Nguyen, Lena H., et al.
Publicado: (2023)

Cinobufagin alleviates lipopolysaccharide-induced acute lung injury by regulating autophagy through activation of the p53/mTOR pathway
por: Wang, Cheng, et al.
Publicado: (2022)

8-Gingerol Ameliorates Myocardial Fibrosis by Attenuating Reactive Oxygen Species, Apoptosis, and Autophagy via the PI3K/Akt/mTOR Signaling Pathway
por: Xue, Yucong, et al.
Publicado: (2021)

Trilateral association of autophagy, mTOR and Alzheimer’s disease: Potential pathway in the development for Alzheimer’s disease therapy
por: Subramanian, Arunkumar, et al.
Publicado: (2022)

Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis
por: Zhong, Zeyuan, et al.
Publicado: (2020)

mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging
por: Yadav, Rahul B, et al.
Publicado: (2013)

circRNA MYLK Accelerates Cervical Cancer via Up-Regulation of RHEB and Activation of mTOR Signaling
por: Chen, Rui, et al.
Publicado: (2020)

Ubiquitously specific protease 4 inhibitor‐Vialinin A attenuates inflammation and fibrosis in S100‐induced hepatitis mice through Rheb/mTOR signalling
por: Xu, Jie, et al.
Publicado: (2020)

Progress on structural modification of Tetrandrine with wide range of pharmacological activities
por: Mo, Liuying, et al.
Publicado: (2022)

Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway
por: Cui, Lihua, et al.
Publicado: (2021)

Nuciferine induces autophagy to relieve vascular cell adhesion molecule 1 activation via repressing the Akt/mTOR/AP1 signal pathway in the vascular endothelium
por: Wei, Haibin, et al.
Publicado: (2023)

Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats
por: Su, Zuqing, et al.
Publicado: (2021)

Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway
por: Wang, Yue, et al.
Publicado: (2019)

The protective roles of allicin on type 1 diabetes mellitus through AMPK/mTOR mediated autophagy pathway
por: Qian, Rengcheng, et al.
Publicado: (2023)

JNK and Autophagy Independently Contributed to Cytotoxicity of Arsenite combined With Tetrandrine via Modulating Cell Cycle Progression in Human Breast Cancer Cells
por: Yu, Bowen, et al.
Publicado: (2020)

A Worldwide Bibliometric Analysis of Tetrandrine Research in Recent Two Decades
por: Yang, Guang, et al.
Publicado: (2022)

6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
por: Guo, Donghao, et al.
Publicado: (2019)

Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non–Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway
por: Shao, Shali, et al.
Publicado: (2022)

Qianlie Xiaozheng Decoction Induces Autophagy in Human Prostate Cancer Cells via Inhibition of the Akt/mTOR Pathway
por: Xu, Yuehua, et al.
Publicado: (2018)

Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells
por: Qu, Na, et al.
Publicado: (2022)

Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR
por: Huangfu, Yaru, et al.
Publicado: (2023)

Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway
por: Xing, Guoping, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_86s99b55dkvjbrhmq5mkknl247