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Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris
Objectives: Psoriasis is a common chronic recurrent dermatitis. Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development. Design: We first performed an epidemiological investigation...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646027/ https://www.ncbi.nlm.nih.gov/pubmed/34881280 http://dx.doi.org/10.3389/fnut.2021.761978 |
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author | Sun, Chaonan Chen, Ling Yang, Huan Sun, Hongjiang Xie, Zhen Zhao, Bei Jiang, Xuemei Qin, Bi Shen, Zhu |
author_facet | Sun, Chaonan Chen, Ling Yang, Huan Sun, Hongjiang Xie, Zhen Zhao, Bei Jiang, Xuemei Qin, Bi Shen, Zhu |
author_sort | Sun, Chaonan |
collection | PubMed |
description | Objectives: Psoriasis is a common chronic recurrent dermatitis. Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development. Design: We first performed an epidemiological investigation on differences of gastrointestinal discomfort symptoms between patients with psoriasis and general population. Then variation of gut microbiota in patients with psoriasis (un)treated with acitretin plus narrow-band ultraviolet B (NB-UVB) was analyzed by 16S rRNA sequencing. We last compared recovery status and vital cytokines (lesion and intestine) of mouse psoriasiform models, which were transplanted with fecal microbiota from patients with psoriasis or healthy controls. Results: (1) About 85.5% of patients with psoriasis vs. 58.1% of healthy controls presented with at least one gastrointestinal symptom. The prevalence of investigated symptoms (e.g., abdominal distension and constipation) were significantly higher in patients, compared with controls (p < 0.05). Passing flatus and constipation were significantly correlated with psoriasis (p < 0.05 in both cases). (2) The abundance of Ruminococcaceae family, Coprococcus_1 genus, and Blautia genus were decreased with psoriasis improvement (p < 0.05, respectively), which had been demonstrated significantly increased in psoriasis. (3) Mice receiving psoriatic microbes transplantation showed delayed recovery of psoriasiform dermatitis and less reduction of interleukin (IL)-17A than those receiving healthy microbiota or blank control (p < 0.05 and p < 0.01, respectively). Conclusion: Multiple evidence we provided here preliminarily demonstrates the involvement of gut microbiota in the different degree of psoriasis activity. The strategy based on overall microbial communities is expected to be a promising supplementary for long-term management of psoriasis. |
format | Online Article Text |
id | pubmed-8646027 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86460272021-12-07 Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris Sun, Chaonan Chen, Ling Yang, Huan Sun, Hongjiang Xie, Zhen Zhao, Bei Jiang, Xuemei Qin, Bi Shen, Zhu Front Nutr Nutrition Objectives: Psoriasis is a common chronic recurrent dermatitis. Accumulating observations show gut microbiota dysbiosis in psoriasis. We intend to further investigate the relationship between intestinal microbiota and psoriasis development. Design: We first performed an epidemiological investigation on differences of gastrointestinal discomfort symptoms between patients with psoriasis and general population. Then variation of gut microbiota in patients with psoriasis (un)treated with acitretin plus narrow-band ultraviolet B (NB-UVB) was analyzed by 16S rRNA sequencing. We last compared recovery status and vital cytokines (lesion and intestine) of mouse psoriasiform models, which were transplanted with fecal microbiota from patients with psoriasis or healthy controls. Results: (1) About 85.5% of patients with psoriasis vs. 58.1% of healthy controls presented with at least one gastrointestinal symptom. The prevalence of investigated symptoms (e.g., abdominal distension and constipation) were significantly higher in patients, compared with controls (p < 0.05). Passing flatus and constipation were significantly correlated with psoriasis (p < 0.05 in both cases). (2) The abundance of Ruminococcaceae family, Coprococcus_1 genus, and Blautia genus were decreased with psoriasis improvement (p < 0.05, respectively), which had been demonstrated significantly increased in psoriasis. (3) Mice receiving psoriatic microbes transplantation showed delayed recovery of psoriasiform dermatitis and less reduction of interleukin (IL)-17A than those receiving healthy microbiota or blank control (p < 0.05 and p < 0.01, respectively). Conclusion: Multiple evidence we provided here preliminarily demonstrates the involvement of gut microbiota in the different degree of psoriasis activity. The strategy based on overall microbial communities is expected to be a promising supplementary for long-term management of psoriasis. Frontiers Media S.A. 2021-11-22 /pmc/articles/PMC8646027/ /pubmed/34881280 http://dx.doi.org/10.3389/fnut.2021.761978 Text en Copyright © 2021 Sun, Chen, Yang, Sun, Xie, Zhao, Jiang, Qin and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Sun, Chaonan Chen, Ling Yang, Huan Sun, Hongjiang Xie, Zhen Zhao, Bei Jiang, Xuemei Qin, Bi Shen, Zhu Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris |
title | Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris |
title_full | Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris |
title_fullStr | Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris |
title_full_unstemmed | Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris |
title_short | Involvement of Gut Microbiota in the Development of Psoriasis Vulgaris |
title_sort | involvement of gut microbiota in the development of psoriasis vulgaris |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646027/ https://www.ncbi.nlm.nih.gov/pubmed/34881280 http://dx.doi.org/10.3389/fnut.2021.761978 |
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