DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome

Critical mutations of mitochondrial DNA (mtDNA) generally lead to maternally inheritable diseases that affect multiple organs and systems; however, it was difficult to alter mtDNA in mammalian cells to intervene in or cure mitochondrial disorders. Recently, the discovery of DddA-derived cytosine bas...

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Detalles Bibliográficos
Autores principales: Guo, Jiayin, Chen, Xiaoxu, Liu, Zhiwei, Sun, Haifeng, Zhou, Yu, Dai, Yichen, Ma, Yu'e, He, Lei, Qian, Xuezhen, Wang, Jianying, Zhang, Jie, Zhu, Yichen, Zhang, Jun, Shen, Bin, Zhou, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646052/
https://www.ncbi.nlm.nih.gov/pubmed/34938607
http://dx.doi.org/10.1016/j.omtn.2021.11.016

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