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circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis

Glioma is a common intracranial malignant tumor with high mortality and high recurrence rate. In recent years, increasing evidence has demonstrated that circular RNAs (circRNAs) are potential biomarkers and therapeutic targets for many tumors. However, the role of circRNAs in glioma remains unclear....

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Autores principales: Xia, Haibin, Liu, Boyang, Shen, Nanxiang, Xue, Jinhua, Chen, Siyu, Guo, Hongbo, Zhou, Xiaozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646083/
https://www.ncbi.nlm.nih.gov/pubmed/34938603
http://dx.doi.org/10.1016/j.omtn.2021.11.011
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author Xia, Haibin
Liu, Boyang
Shen, Nanxiang
Xue, Jinhua
Chen, Siyu
Guo, Hongbo
Zhou, Xiaozhong
author_facet Xia, Haibin
Liu, Boyang
Shen, Nanxiang
Xue, Jinhua
Chen, Siyu
Guo, Hongbo
Zhou, Xiaozhong
author_sort Xia, Haibin
collection PubMed
description Glioma is a common intracranial malignant tumor with high mortality and high recurrence rate. In recent years, increasing evidence has demonstrated that circular RNAs (circRNAs) are potential biomarkers and therapeutic targets for many tumors. However, the role of circRNAs in glioma remains unclear. In this study, we found that circRNA-0002109 was highly expressed in glioma tissues and cell lines. Downregulation of circRNA-0002109 expression inhibited the proliferation, migration, and invasion of glioma cells and inhibited the malignant progression of tumors in vivo. Investigations into the relevant mechanisms showed that circRNA-0002109 upregulated the expression of EMP2 through endogenous competitive binding of microRNA-129-5P (miR-129-5P), which partially alleviated the inhibitory effect of miR-129-5P on epithelial membrane protein-2 (EMP2) and ultimately promoted the malignant development of glioma. Our results indicate that circRNA-0002109 plays an important role in the proliferation, invasion, and migration of glioma cells by regulating the miR-129-5P/EMP2 axis, which provides a new potential therapeutic target for glioma.
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spelling pubmed-86460832021-12-21 circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis Xia, Haibin Liu, Boyang Shen, Nanxiang Xue, Jinhua Chen, Siyu Guo, Hongbo Zhou, Xiaozhong Mol Ther Nucleic Acids Original Article Glioma is a common intracranial malignant tumor with high mortality and high recurrence rate. In recent years, increasing evidence has demonstrated that circular RNAs (circRNAs) are potential biomarkers and therapeutic targets for many tumors. However, the role of circRNAs in glioma remains unclear. In this study, we found that circRNA-0002109 was highly expressed in glioma tissues and cell lines. Downregulation of circRNA-0002109 expression inhibited the proliferation, migration, and invasion of glioma cells and inhibited the malignant progression of tumors in vivo. Investigations into the relevant mechanisms showed that circRNA-0002109 upregulated the expression of EMP2 through endogenous competitive binding of microRNA-129-5P (miR-129-5P), which partially alleviated the inhibitory effect of miR-129-5P on epithelial membrane protein-2 (EMP2) and ultimately promoted the malignant development of glioma. Our results indicate that circRNA-0002109 plays an important role in the proliferation, invasion, and migration of glioma cells by regulating the miR-129-5P/EMP2 axis, which provides a new potential therapeutic target for glioma. American Society of Gene & Cell Therapy 2021-11-19 /pmc/articles/PMC8646083/ /pubmed/34938603 http://dx.doi.org/10.1016/j.omtn.2021.11.011 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Xia, Haibin
Liu, Boyang
Shen, Nanxiang
Xue, Jinhua
Chen, Siyu
Guo, Hongbo
Zhou, Xiaozhong
circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_full circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_fullStr circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_full_unstemmed circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_short circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis
title_sort circrna-0002109 promotes glioma malignant progression via modulating the mir-129-5p/emp2 axis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646083/
https://www.ncbi.nlm.nih.gov/pubmed/34938603
http://dx.doi.org/10.1016/j.omtn.2021.11.011
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