SARS‐CoV‐2 variants as super cell fusers: cause or consequence of COVID‐19 severity?

The most severe forms of coronavirus disease 2019 (COVID‐19) are often associated with the presence of syncytia in the lungs resulting from cell–cell fusion mediated by the SARS‐CoV‐2 spike protein. In this issue, Rajah and colleagues show that the SARS‐CoV‐2 alpha, beta, and delta variants promote...

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Detalles Bibliográficos
Autores principales: Koch, Jana, Uckeley, Zina M, Lozach, Pierre‐Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646788/
https://www.ncbi.nlm.nih.gov/pubmed/34779518
http://dx.doi.org/10.15252/embj.2021110041
Descripción
Sumario:The most severe forms of coronavirus disease 2019 (COVID‐19) are often associated with the presence of syncytia in the lungs resulting from cell–cell fusion mediated by the SARS‐CoV‐2 spike protein. In this issue, Rajah and colleagues show that the SARS‐CoV‐2 alpha, beta, and delta variants promote enhanced syncytia formation as compared to the original strain.

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