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Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis

OBJECTIVE: To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality. METHODS: This retrospective case–control study analysed data from patients with SCA that experienced VTE compared wi...

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Autores principales: Alkindi, Salam, Al-Ghadani, Anwaar R, Al-Zeheimi, Samah R, Alkindi, Said Y, Fawaz, Naglaa, Ballas, Samir K, Pathare, Anil V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646795/
https://www.ncbi.nlm.nih.gov/pubmed/34855536
http://dx.doi.org/10.1177/03000605211055385
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author Alkindi, Salam
Al-Ghadani, Anwaar R
Al-Zeheimi, Samah R
Alkindi, Said Y
Fawaz, Naglaa
Ballas, Samir K
Pathare, Anil V
author_facet Alkindi, Salam
Al-Ghadani, Anwaar R
Al-Zeheimi, Samah R
Alkindi, Said Y
Fawaz, Naglaa
Ballas, Samir K
Pathare, Anil V
author_sort Alkindi, Salam
collection PubMed
description OBJECTIVE: To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality. METHODS: This retrospective case–control study analysed data from patients with SCA that experienced VTE compared with matched control patients with SCA but no VTE (2:1 ratio). RESULTS: A total of 102 patients with SCA were enrolled (68 cases with VTE and 34 controls). Amongst the 68 cases (median age, 29.5 years), 26 (38.2%) presented with isolated pulmonary embolism (PE). A higher prevalence of splenectomy (73.5% versus 35.3%) was observed in the cases compared with the controls. A significantly higher prevalence of central venous catheter (CVC) insertion (42.6% versus 8.8%) was observed in the cases compared with the controls. High white blood cell counts, serum lactic dehydrogenase (LDH), bilirubin and C-reactive protein (CRP) and low haemoglobin (Hb) and HbF were significant risk factors for VTE. Forty-two cases (61.8%) developed acute chest syndrome, 10 (14.7%) had a stroke and seven (10.3%) died. CONCLUSIONS: VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors.
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spelling pubmed-86467952021-12-07 Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis Alkindi, Salam Al-Ghadani, Anwaar R Al-Zeheimi, Samah R Alkindi, Said Y Fawaz, Naglaa Ballas, Samir K Pathare, Anil V J Int Med Res Retrospective Clinical Research Report OBJECTIVE: To assess the clinical and laboratory predictors of venous thromboembolism (VTE) in patients with sickle cell anaemia (SCA) and its relationship to morbidity and mortality. METHODS: This retrospective case–control study analysed data from patients with SCA that experienced VTE compared with matched control patients with SCA but no VTE (2:1 ratio). RESULTS: A total of 102 patients with SCA were enrolled (68 cases with VTE and 34 controls). Amongst the 68 cases (median age, 29.5 years), 26 (38.2%) presented with isolated pulmonary embolism (PE). A higher prevalence of splenectomy (73.5% versus 35.3%) was observed in the cases compared with the controls. A significantly higher prevalence of central venous catheter (CVC) insertion (42.6% versus 8.8%) was observed in the cases compared with the controls. High white blood cell counts, serum lactic dehydrogenase (LDH), bilirubin and C-reactive protein (CRP) and low haemoglobin (Hb) and HbF were significant risk factors for VTE. Forty-two cases (61.8%) developed acute chest syndrome, 10 (14.7%) had a stroke and seven (10.3%) died. CONCLUSIONS: VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors. SAGE Publications 2021-12-02 /pmc/articles/PMC8646795/ /pubmed/34855536 http://dx.doi.org/10.1177/03000605211055385 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Alkindi, Salam
Al-Ghadani, Anwaar R
Al-Zeheimi, Samah R
Alkindi, Said Y
Fawaz, Naglaa
Ballas, Samir K
Pathare, Anil V
Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_full Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_fullStr Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_full_unstemmed Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_short Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
title_sort predicting risk factors for thromboembolic complications in patients with sickle cell anaemia – lessons learned for prophylaxis
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646795/
https://www.ncbi.nlm.nih.gov/pubmed/34855536
http://dx.doi.org/10.1177/03000605211055385
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