Modulation of muscle redox and protein aggregation rescues lethality caused by mutant lamins

Mutations in the human LMNA gene cause a collection of diseases called laminopathies, which includes muscular dystrophy and dilated cardiomyopathy. The LMNA gene encodes lamins, filamentous proteins that form a meshwork on the inner side of the nuclear envelope. How mutant lamins cause muscle diseas...

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Detalles Bibliográficos
Autores principales: Coombs, Gary S., Rios-Monterrosa, Jose L., Lai, Shuping, Dai, Qiang, Goll, Ashley C., Ketterer, Margaret R., Valdes, Maria F., Uche, Nnamdi, Benjamin, Ivor J., Wallrath, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646998/
https://www.ncbi.nlm.nih.gov/pubmed/34872044
http://dx.doi.org/10.1016/j.redox.2021.102196

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