Muscle‐specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling

The mechanistic target of rapamycin (mTOR) promotes pathological remodeling in the heart by activating ribosomal biogenesis and mRNA translation. Inhibition of mTOR in cardiomyocytes is protective; however, a detailed role of mTOR in translational regulation of specific mRNA networks in the diseased...

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Autores principales: Górska, Agnieszka A, Sandmann, Clara, Riechert, Eva, Hofmann, Christoph, Malovrh, Ellen, Varma, Eshita, Kmietczyk, Vivien, Ölschläger, Julie, Jürgensen, Lonny, Kamuf‐Schenk, Verena, Stroh, Claudia, Furkel, Jennifer, Konstandin, Mathias H, Sticht, Carsten, Boileau, Etienne, Dieterich, Christoph, Frey, Norbert, Katus, Hugo A, Doroudgar, Shirin, Völkers, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647021/
https://www.ncbi.nlm.nih.gov/pubmed/34605609
http://dx.doi.org/10.15252/embr.202052170

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