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Adaptive homeostasis and the p53 isoform network
All living organisms have developed processes to sense and address environmental changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour suppressor maintains cell and organ integrity and functions in response to homeostasis disruptors (stresses) such as infection, m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647153/ https://www.ncbi.nlm.nih.gov/pubmed/34779563 http://dx.doi.org/10.15252/embr.202153085 |
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author | Mehta, Sunali Campbell, Hamish Drummond, Catherine J Li, Kunyu Murray, Kaisha Slatter, Tania Bourdon, Jean‐Christophe Braithwaite, Antony W |
author_facet | Mehta, Sunali Campbell, Hamish Drummond, Catherine J Li, Kunyu Murray, Kaisha Slatter, Tania Bourdon, Jean‐Christophe Braithwaite, Antony W |
author_sort | Mehta, Sunali |
collection | PubMed |
description | All living organisms have developed processes to sense and address environmental changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour suppressor maintains cell and organ integrity and functions in response to homeostasis disruptors (stresses) such as infection, metabolic alterations and cellular damage. Thus, p53 plays a fundamental physiological role in maintaining organismal homeostasis. The TP53 gene encodes a network of proteins (p53 isoforms) with similar and distinct biochemical functions. The p53 network carries out multiple biological activities enabling cooperation between individual cells required for long‐term survival of multicellular organisms (animals) in response to an ever‐changing environment caused by mutation, infection, metabolic alteration or damage. In this review, we suggest that the p53 network has evolved as an adaptive response to pathogen infections and other environmental selection pressures. |
format | Online Article Text |
id | pubmed-8647153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86471532021-12-20 Adaptive homeostasis and the p53 isoform network Mehta, Sunali Campbell, Hamish Drummond, Catherine J Li, Kunyu Murray, Kaisha Slatter, Tania Bourdon, Jean‐Christophe Braithwaite, Antony W EMBO Rep Review All living organisms have developed processes to sense and address environmental changes to maintain a stable internal state (homeostasis). When activated, the p53 tumour suppressor maintains cell and organ integrity and functions in response to homeostasis disruptors (stresses) such as infection, metabolic alterations and cellular damage. Thus, p53 plays a fundamental physiological role in maintaining organismal homeostasis. The TP53 gene encodes a network of proteins (p53 isoforms) with similar and distinct biochemical functions. The p53 network carries out multiple biological activities enabling cooperation between individual cells required for long‐term survival of multicellular organisms (animals) in response to an ever‐changing environment caused by mutation, infection, metabolic alteration or damage. In this review, we suggest that the p53 network has evolved as an adaptive response to pathogen infections and other environmental selection pressures. John Wiley and Sons Inc. 2021-11-15 2021-12-06 /pmc/articles/PMC8647153/ /pubmed/34779563 http://dx.doi.org/10.15252/embr.202153085 Text en © 2021 The Authors. Published under the terms of the CC BY 4.0 license https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Mehta, Sunali Campbell, Hamish Drummond, Catherine J Li, Kunyu Murray, Kaisha Slatter, Tania Bourdon, Jean‐Christophe Braithwaite, Antony W Adaptive homeostasis and the p53 isoform network |
title | Adaptive homeostasis and the p53 isoform network |
title_full | Adaptive homeostasis and the p53 isoform network |
title_fullStr | Adaptive homeostasis and the p53 isoform network |
title_full_unstemmed | Adaptive homeostasis and the p53 isoform network |
title_short | Adaptive homeostasis and the p53 isoform network |
title_sort | adaptive homeostasis and the p53 isoform network |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647153/ https://www.ncbi.nlm.nih.gov/pubmed/34779563 http://dx.doi.org/10.15252/embr.202153085 |
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