Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology and altered phenotypes of plaque-associated microglia. Here, we show that a short, 7-d treatment of preweaned male mice with high...

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Detalles Bibliográficos
Autores principales: Dodiya, Hemraj B., Lutz, Holly L., Weigle, Ian Q., Patel, Priyam, Michalkiewicz, Julia, Roman-Santiago, Carlos J., Zhang, Can Martin, Liang, Yingxia, Srinath, Abhinav, Zhang, Xulun, Xia, Jessica, Olszewski, Monica, Zhang, Xiaoqiong, Schipma, Matthew John, Chang, Eugene B., Tanzi, Rudolph E., Gilbert, Jack A., Sisodia, Sangram S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647415/
https://www.ncbi.nlm.nih.gov/pubmed/34854884
http://dx.doi.org/10.1084/jem.20200895

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