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Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)

Preclinical research is a vital step in the drug discovery pipeline and more generally in helping to better understand human disease aetiology and its management. Systematic reviews (SRs) can be powerful in summarising and appraising this evidence concerning a specific research question, to highligh...

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Autores principales: Bahor, Zsanett, Liao, Jing, Currie, Gillian, Ayder, Can, Macleod, Malcolm, McCann, Sarah K, Bannach-Brown, Alexandra, Wever, Kimberley, Soliman, Nadia, Wang, Qianying, Doran-Constant, Lee, Young, Laurie, Sena, Emily S, Sena, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647599/
https://www.ncbi.nlm.nih.gov/pubmed/35047698
http://dx.doi.org/10.1136/bmjos-2020-100103
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author Bahor, Zsanett
Liao, Jing
Currie, Gillian
Ayder, Can
Macleod, Malcolm
McCann, Sarah K
Bannach-Brown, Alexandra
Wever, Kimberley
Soliman, Nadia
Wang, Qianying
Doran-Constant, Lee
Young, Laurie
Sena, Emily S
Sena, Chris
author_facet Bahor, Zsanett
Liao, Jing
Currie, Gillian
Ayder, Can
Macleod, Malcolm
McCann, Sarah K
Bannach-Brown, Alexandra
Wever, Kimberley
Soliman, Nadia
Wang, Qianying
Doran-Constant, Lee
Young, Laurie
Sena, Emily S
Sena, Chris
author_sort Bahor, Zsanett
collection PubMed
description Preclinical research is a vital step in the drug discovery pipeline and more generally in helping to better understand human disease aetiology and its management. Systematic reviews (SRs) can be powerful in summarising and appraising this evidence concerning a specific research question, to highlight areas of improvements, areas for further research and areas where evidence may be sufficient to take forward to other research domains, for instance clinical trial. Guidance and tools for preclinical research synthesis remain limited despite their clear utility. We aimed to create an online end-to-end platform primarily for conducting SRs of preclinical studies, that was flexible enough to support a wide variety of experimental designs, was adaptable to different research questions, would allow users to adopt emerging automated tools and support them during their review process using best practice. In this article, we introduce the Systematic Review Facility (https://syrf.org.uk), which was launched in 2016 and designed to support primarily preclinical SRs from small independent projects to large, crowdsourced projects. We discuss the architecture of the app and its features, including the opportunity to collaborate easily, to efficiently manage projects, to screen and annotate studies for important features (metadata), to extract outcome data into a secure database, and tailor these steps to each project. We introduce how we are working to leverage the use of automation tools and allow the integration of these services to accelerate and automate steps in the systematic review workflow.
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spelling pubmed-86475992022-01-18 Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF) Bahor, Zsanett Liao, Jing Currie, Gillian Ayder, Can Macleod, Malcolm McCann, Sarah K Bannach-Brown, Alexandra Wever, Kimberley Soliman, Nadia Wang, Qianying Doran-Constant, Lee Young, Laurie Sena, Emily S Sena, Chris BMJ Open Sci Original Research Preclinical research is a vital step in the drug discovery pipeline and more generally in helping to better understand human disease aetiology and its management. Systematic reviews (SRs) can be powerful in summarising and appraising this evidence concerning a specific research question, to highlight areas of improvements, areas for further research and areas where evidence may be sufficient to take forward to other research domains, for instance clinical trial. Guidance and tools for preclinical research synthesis remain limited despite their clear utility. We aimed to create an online end-to-end platform primarily for conducting SRs of preclinical studies, that was flexible enough to support a wide variety of experimental designs, was adaptable to different research questions, would allow users to adopt emerging automated tools and support them during their review process using best practice. In this article, we introduce the Systematic Review Facility (https://syrf.org.uk), which was launched in 2016 and designed to support primarily preclinical SRs from small independent projects to large, crowdsourced projects. We discuss the architecture of the app and its features, including the opportunity to collaborate easily, to efficiently manage projects, to screen and annotate studies for important features (metadata), to extract outcome data into a secure database, and tailor these steps to each project. We introduce how we are working to leverage the use of automation tools and allow the integration of these services to accelerate and automate steps in the systematic review workflow. BMJ Publishing Group 2021-03-30 /pmc/articles/PMC8647599/ /pubmed/35047698 http://dx.doi.org/10.1136/bmjos-2020-100103 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Research
Bahor, Zsanett
Liao, Jing
Currie, Gillian
Ayder, Can
Macleod, Malcolm
McCann, Sarah K
Bannach-Brown, Alexandra
Wever, Kimberley
Soliman, Nadia
Wang, Qianying
Doran-Constant, Lee
Young, Laurie
Sena, Emily S
Sena, Chris
Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)
title Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)
title_full Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)
title_fullStr Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)
title_full_unstemmed Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)
title_short Development and uptake of an online systematic review platform: the early years of the CAMARADES Systematic Review Facility (SyRF)
title_sort development and uptake of an online systematic review platform: the early years of the camarades systematic review facility (syrf)
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647599/
https://www.ncbi.nlm.nih.gov/pubmed/35047698
http://dx.doi.org/10.1136/bmjos-2020-100103
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